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. 2022 Dec 15;13:7766. doi: 10.1038/s41467-022-35303-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Quantitative PCR analysis of posterior Hox gene expression within tailbud tissue isolated from TCre^ERT2 controls, TCre^ERT2;Nr6a1^+/flx and TCre^ERT2;Nr6a1^flx/flx embryos at E9.5, n = 3 biologically independent samples per genotype. Statistical analysis of differences between genotypes was performed using an unpaired two-sample Welch’s t test, p values are provided in the figure. Source data are provided as a Source Data file. B Whole mount in situ hybridisation revealed a spatial expansion of Hoxb13 expression in TCre^ERT2;Nr6a1^+/flxembryos compared to wildtype, at both E9.5 and E10.5. Red arrow at E9.5 indicates ectopic Hoxb13 expression. TBM = tail bud mesoderm; NT = neural tube.