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. 2022 Dec 15;13:7766. doi: 10.1038/s41467-022-35303-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A Skeletal preparation of E18.5 embryos, lateral view, revealed a dose-dependent rescue of Gdf11^−/− thoraco-lumbar expansion following conditional deletion of Nr6a1 alleles. The number of biologically independent samples assessed: Nr6a1^+/+;Gdf11^−/− n = 9; Nr6a1^+/−;Gdf11^−/− n = 5; Nr6a1^−/−;Gdf11^−/− n = 7. T = thoracic, L = lumbar. B Quantification of thoracic, lumbar and sacro-caudal vertebral number across genotypes. Raw data is presented in the upper plots. Mean differences were calculated relative to Gdf11^−/−;Nr6a1^+/+ and presented in the lower plots as bootstrap sampling distributions. The mean difference for each genotype is depicted as a black dot and 95% confidence interval is indicated by the ends of the vertical error bar.