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. 2022 Dec 15;13:7766. doi: 10.1038/s41467-022-35303-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — A, B Differential Hox expression kinetics observed during in vitro differentiation of Nr6a1 and wildtype ESCs. Source data are provided as a Source Data file. A RNAseq analysis of trunk Hox gene expression (Hox6-9) in Nr6a1^−/− (red) and wildtype (blue) cells. In vitro differentiation protocol schematised, analysis timepoints marked with asterisk and data represented as counts per million (CPM). Only those genes showing a false discovery rate (FDR) < 0.05 are visualised. B RNAseq analysis of posterior Hox gene expression (Hox10-13) in Nr6a1^−/− (red) and wildtype (blue) cells. In vitro differentiation protocol schematised, analysis timepoints marked with asterisk and data represented as counts per million (CPM). Only those genes showing a false discovery rate (FDR) < 0.05 are visualised. G = addition of Gdf11.