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. 2022 Dec 15;13:7778. doi: 10.1038/s41467-022-35503-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a In vivo dosing schedule for in vivo echocardiography evaluation. b–f Left ventricular ejection fractions of mice in different groups by echocardiography inspections: b ECG Ctl (n = 6); c ECG I (n = 8); d ECG II (n = 8); e ECG III (n = 8); f ECG IV (n = 8). Data are presented as they are and mean (line) ± s.d. (bounds of box). Statistical significance is assessed by Student t’s two-tailed test. *P < 0.05, **P < 0.01, ***P < 0.001 and n.s. for non-significant. g and h, Raw (g) and normalized LVEF levels (h) of mice by different ECG inspections for different groups. Data are presented as mean ± s.d. Statistical significance (to the control group) is assessed by Student t’s two-tailed test. ***P < 0.001 and n.s. for non-significant. i Representative echocardiographic images for mice in different groups by echocardiography inspections.