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. 2022 Dec 2;9:1067406. doi: 10.3389/fmolb.2022.1067406

FIGURE 2.

FIGURE 2

Detailed mechanism for DNA methylation regulation by lncRNAs in direct mode. (A). LncRNAs recruit DNMTs to genome loci; (B). LncRNAs sequester DNMTs from genome loci; (C). LncRNAs regulate expression level of DNMTs; (D). LncRNAs function as ceRNA to regulate DNMT expression level; (E). LncRNAs influence the ubiquitination of DNMT proteins to affect the degradation. (F). LncRNAs promote subcellular location of DNMT proteins. It is worth noting that similar mechanisms also applies to TET family members.