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. 2022 Dec 2;9:1067406. doi: 10.3389/fmolb.2022.1067406

TABLE 3.

Representative circRNAs that regulate DNA methylation of other genes in cancers and other disease.

CircRNA name Cofactor Interaction mode Target Tissue/disease Function References
ACR DNMT3B Recruit Pink1 Myocardial ischemia/infarction Autophagy Zhou et al. (2019b)
Circ_6790 CBX7—DNMTs Recruit S100A11 Pancreatic ductal adenocarcinoma Cell proliferation, apoptosis, metastasis, immune escape Gao et al. (2022)
Hsa_circ_001291 DNMT1 Expression CD11a; CD70 Systemic lupus erythematosus Zhang et al. (2018)
Circ-Amotl1 STAT3—DNMT3A Expression miR-17-5p Wound healing Cell adhesion, migration, proliferation, wound repair Yang et al. (2017)
FECR1 TET1; DNMT1 Recruit; expression FLI1; SERTED2 Breast cancer Tumor invasion, metastasis Chen et al. (2018)
Circ_0040809 miR-515-5p—DNMT1 ceRNA Colorectal cancer Cell proliferation, migration, apoptosis Mao et al. (2021)
CircSOD2 miR-502-5p—DNMT3A ceRNA SOCS3 Hepatocellular carcinoma JAK2/STAT3 signaling Zhao et al. (2020b)
CircMEMO1 miR-106b-5p—TET1 ceRNA TCF21 Hepatocellular carcinoma Cell proliferation, invasion, metastasis, EMT, sorafenib sensitivity Dong et al. (2021)
CircTRIM33–12 miR-191—TET1 ceRNA WWC3; TP53INP1; ULBP1; JHDM1D Hepatocellular carcinoma Cell proliferation, migration, invasion, immune evasion Zhang et al. (2019a)
CircIBTK miR-29b Genome wide Systemic lupus erythematosus AKT signaling Zhang et al. (2019a)
Circ-ATAD1 miR-34b Acute myeloid leukemia Cell proliferation Wu et al. (2021b)
Circ-ATAD1 miR-10a Endometrial cancer Cell invasion, migration Yang et al. (2021a)
CircFAT1 miR-21 Endometrial cancer Cell stemness increase Wu et al. (2021a)
CircSEPT9 miR-186 Endometrial cancer Cell invasion, migration Guo et al. (2022)
CircRIMS miR-613 Esophageal squamous cell carcinoma Cell proliferation Wan et al. (2021)
CircSKA3 miR-1 Glioblastoma Cell proliferation Zhou et al. (2021a)
CircFADS2 miR-195-5p Osteoarthritis Apoptosis Zhang et al. (2021b)