Table 3. Inhibition of helicase activity of different prokaryotic helicases by myricetin.

Helicase	IC50 (µM)	Association state	Polarity	Function	References
IC50 values are averages of at least two independent experiments.
RepA	50	Hexameric	5′ → 3′	RSF1010 replication	(14)
SPP1 G40P	0.3	Hexameric	5′ → 3′	SPP1 replication	(37)
P1 Ban	2.5	Hexamerica	5′ → 3′	P1 and E.coli replication	(36)
P4 α	5	≥Dimeric	3′ → 5′	P4 replication	(38)
B.subtilis PcrA	2	Monomeric	3′ → 5′	Unclear	(39)
E.coli Rep	2	Mono-/dimericb	3′ → 5′	Rolling-circle replication	(40,41)
E.coli UvrD (Helicase II)	1.5	Mono-/dimeric	3′ → 5′	DNA repair	(42)
R1 TraI	>10	Monomeric	5′ → 3′	Conjugative DNA transfer	(43)

^aZiegelin and Lanka, unpublished data.

^bCrystallized as monomer.