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. 2022 Dec 2;13:1052182. doi: 10.3389/fimmu.2022.1052182

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Copyright © 2022 Cheng, Wei, Fu, Li and Han

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Construction of the four-gene prognostic risk model based on the TCGA-COAD cohort. (A) Screening of optimal parameters (lambda) in the LASSO regression model based on the TCGA cohort. (B) LASSO coefficient profiles of the 4 ERDEGs determined by the optimal lambda. (C) The Kaplan-Meier survival curve for the OS of patients with COAD patients in the high- and low-risk groups from TCGA cohort. (D) The ROC curve of the prognostic model shows the OS and survival status in TCGA cohort. (E) Scatterplots at the top and bottom show the distribution of the risk score and survival status in patients with COAD, respectively. (F) Univariate and multivariate Cox regression analyses of the risk score and clinicopathological parameters in TCGA cohort.