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. 2022 Dec 2;13:1056369. doi: 10.3389/fphys.2022.1056369

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Copyright © 2022 Lopez, Malacarne, Ramanujam, Warwick, Müller, Hu, Dewenter, Weigert, Günther, Gilsbach, Engelhardt, Brandes and Rezende.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cytochrome P450 reductase and its cardiac CYP450 repertoire. (A) Enrichement of CYP450 genes in different cardiac cell types isolated from healthy murine heart (RNA-sequencing). MP: macrophages, CF: cardiac fibroblasts, EC: endothelial cells, CM: cardiac myocytes. (B) Western blotting for POR expression in cardiac endothelial cell (EC) and heart fraction from control (CTL) and ecPOR^−/− mice. (C) Ratio of heart weight (HW, mg) to body weight (BW, g). n ≥ 11. Body weight CTL: 35.94 ± 2.56; Body weight ecPOR^−/−: 36.33 ± 2.92. (D) Area of cardiac myocyte as determined by Wheat Germ Agglutinin (WGA) staining. n ≥ 7 scale bar: 50 μm *p < 0.05 ecPOR^−/− as compared to CTL mice, Mann-Whitney test.