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. 2022 Dec 2;13:1056369. doi: 10.3389/fphys.2022.1056369

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Copyright © 2022 Lopez, Malacarne, Ramanujam, Warwick, Müller, Hu, Dewenter, Weigert, Günther, Gilsbach, Engelhardt, Brandes and Rezende.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RNA-sequencing of isolated cardiac endothelial cells and left ventricle. (A) Volcano plot summarizing the significantly altered genes in EC. n = 3 (pool of 2 different animals, genes were plotted according to p-value). (B) Ontology analysis (GO Biological Process, 2021; Chen et al., 2013; Kuleshov et al., 2016; Xie et al., 2021) for the top 500 up and downregulated genes of cardiac ECs. Bars represent the percentage of overlapping genes from the top ten analyzed ontologies. (C) Volcano plot summarizing the significantly altered genes in the heart. n = 3. (D) Ontology analysis (GO Biological Process, 2021; Chen et al., 2013; Kuleshov et al., 2016; Xie et al., 2021) for the top 200 up and downregulated genes of the left ventricle. Bars represent the percentage of overlapping genes from the top ten analyzed ontologies. n = 3. *p < 0.05.