FIGURE 4.

Endothelial deletion of POR accelerates heart failure in a model of pressure overload. (A) Schematic representation of the TAC (transverse aortic constriction) using O-ring aortic banding (ORAB; ID: 0.50 mm). (B–G) Cardiac parameters measured by echocardiography as indicated at baseline (0), 7, 14, 21, 28, 35, 42, 49, 56 and 61 days post TAC surgery. n ≥ 5, *p < 0.05 ecPOR^−/− as compared to CTL mice, Two-Way ANOVA for repeated mesurements. (H) Ratio of heart weight (HW) and lung weight (LW) to body weight.