TABLE 2.

Genotype-phenotype association obtained with PhenoScanner (http://www.phenoscanner.medschl.cam.ac.uk/) for cardiac CYP450 isoenzymes.

Gene (human)	Gene (mouse)	rsll)	Position	Base	Base	Trait	Type	p-value
CYP1A1	Cyplal	rs17861084	chrl5:75O12O19	T	G	Total cholesterol	Diseases and traits	6.14E-1O
		rs17861084	chrl5:75012019	T	G	Triglycerides	Diseases andtraits	121E-07
CYP4B1	Cyp4bl	rs45468297	chrl:47282626	A	G	Cause of death: congestive heart failure	Diseases andtraits	7.36E-13
CYP4F2	Cyp4fl3	rs30931 11	chrl9:1600777O	A	G	LDL cholesterol	Diseases and traits	9.45E-09
		rs3093193	chrl9:15991914	C	G	Coronaryarterydisease	Diseasesandtraits	2.11E-06
CYP4F11	Cyp4fl6	rs144570608	chrl9:16045076	A	T	Cause of death: congestive heart failure	Diseases andtraits	2.82E-16
CYP4F12	Cyp4fl7	s538943818	chrl9:15794653	T	C	Cause of death: dilated cardiomyopathy	Diseases and traits	4.38E-15
		s55O467O38	chrl9:15802300	T	C	Cause of death: hypertensive heart disease with heart failure	Diseases and traits	1.33E-08
CYP4V2	Cyp4v3	rs532291947	chr4:187134385	T	C	Cause of death: ischaemic cardiomyopathy	Diseases andtraits	1.59E-12
CYP2J2	-	rs11572277	chrl:60374467	A	G	Cause of death: heart failure, unspecified	Diseases and traits	1.05E-07
		rs41287722	chrl:60359036	A	T	Cause of death: ischaemic cardiomyopathy	Diseases and traits	1.48E-07
CYP2C8	Cyp2c8	s56553776O	chrlO:96802435	A	G	Cause of death: peripheml vascular disease, unspecified	Diseases and traits	1.57E-18
		T8188011311	chrlO:96825092	T	C	Cause of death: dilated cardiomyopathy	Diseases andtraits	6.45E-18
CYP2C9	Cyp2c9	s55315O888	chrlO:96734381	A	G	Cause of death: peripheml vascular disease, unspecified	Diseases andtraits	9.95E-30
POR	Por	T8181538359	chr7:75566011	T	G	Cause of death: peripheml vascular disease, unspecified	Diseases and traits	6.59E-25
		T8113454523	chr7:75555973	A	G	Cause of death: congestive heart failure	Diseases and traits	1.32E-06