Figure 1.

Exon structure of MAPT. The exon structure of MAPT derived from the Ensemble and NCBI databases includes alternative splicing at the N-terminal with either exons 2 and 3 or exon 2 alone labeled in green (exon 3 is always associated with exon 2), exon 4a or its longer form of 4a-L defining Big tau labeled in blue, exon 6 with 3 splice sites (6c, 6p, and 6d) labeled in yellow, exon 8 labeled in white, and exon 10, which is one of the MTBD defining the 3R/4R isoforms labeled in red. The constitutive exons 1, 4, 5, 7, and 13 are labeled in gray. Note that these alternative splicing can generate multiple isoforms with distinct temporal and spatial distributions.