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. 2022 Dec 2;12:1016958. doi: 10.3389/fonc.2022.1016958

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Copyright © 2022 Seborova, Hlavac, Holy, Bjørklund, Fleischer, Rob, Hruda, Bouda, Mrhalova, Allah, Vodicka, Fiala, Soucek, Kristensen, Vodickova and Vaclavikova

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overview and pathway classification of DNA repair genes with significant deregulation based on platinum-resistant status. Significant expression changes (DDB2, PRPF19, HELQ, MAD2L2 in red), significant changes in methylation profile (RAD50), significant intersections from eQTL analysis (XPC, PRKDC and FAAP20) and significant intersections from mQTL analysis (BRCA1, RAD9A and RBBP8 in blue). SNV (single nucleotide variant), DEL (deletion), DNV (double nucleotide variant), INS (insertion).