Figure 6.

MyD88 intron 1 has relatively weak splicing regulatory sequences. Depicted are the sequences at the 3’ end of intron 1 in mouse and human MyD88. Sequences involved in facilitating exon 2 inclusion include the AG dinucleotide at the 3’ end of the intron, the polypyrimidine (pY) tract upstream of the AG dinucleotide, and the branch point sequence [identified for human MyD88 in (132)] including the branch point adenosine residue underlined. In red above the branch point is a strong branch point sequence (the reverse complement of the sequence in the U2 snRNA). Figure created with BioRender.com.