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Tumor size model parameters used in the simulation 12
| Parameter | Description (unit) | Estimate | IIV |
|---|---|---|---|
| kG | Tumor growth rate (week−1) | 0.00583 | 1.06 |
| KDE | Tumor growth inhibition rate (week−1) | 0.0498 | 0.63 |
| λ | Exponential decrease in tumor growth inhibition rate (week−1) | 0.0866 | 0.63 |
| Baseline | Tumor baseline SLD (cm) | 9.67 | 0.71 |
| Additive residual error | Unexplained variability (cm) | 0.98 | ‐ |
Abbreviations: IIV, interindividual variability; SLD, sum of longest diameter.
