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. 2022 Dec 14;12(12):e062188. doi: 10.1136/bmjopen-2022-062188

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Volcano plot displaying pairwise comparisons of inflammatory factors in type 2 diabetes and healthy controls. Vertical dashed lines indicate threshold for twofold differences among groups. Horizontal dashed lines indicate p value thresholds of 0.05, 0.01 and 0.001, respectively. ●Significantly different after adjustment for age and BMI, ◓significantly different in the unadjusted model,○ above significance threshold in both models. Only significant analytes are labelled. BMI, body mass index; CRP, C reactive protein; IL, interleukin; MDC, macrophage-derived chemokine; MIP, macrophage inflammatory protein; TNF, tumour necrosis factor.