TABLE 5.

Results of in vivo assessment of the human recombinant antibodies^a

Expt no.	Antibody	Antibody specificity	No. of mice	Colony counts (mean log10 CFU/g ± SD)
				Kidney	Liver	Spleen
1	Unimmunized rabbit		15	7.13 ± 1.3	4.84 ± 2.32	4.11 ± 1.45
	Hyperimmune rabbit	ABC protein	15	6.61 ± 0.98b	3.84 ± 1.28c	3.35 ± 0.36b
2	Negative phage		5	7.86 ± 1.73	5.45 ± 1.73	5.09 ± 1.23
	ABC 6	Peptide 3	5	7.57 ± 1.49	5.74 ± 1.05	4.96 ± 1.03
	ABC 7	Peptide 3	5	7.72 ± 1.47	6.04 ± 1.14	5.74 ± 0.94
	ABC 8	ABC protein	5	7.79 ± 1.79	4.35 ± 1.52c	4.81 ± 2.04
	ABC 9	ABC protein	6	7.32 ± 1.32b	5.3 ± 0.59	4.19 ± 0.26b
3	Negative phage		12	8.23 ± 2.47	6.03 ± 1.35	6.05 ± 1.39
	ABC 1	Peptide 1	9	7.62 ± 1.99b	4.71 ± 0.69c	4.38 ± 1.48c
	ABC 3	Peptide 2	9	8.85 ± 3.27	4.88 ± 0.97c	4.15 ± 0.96c
	ABC 6	Peptide 3	9	7.56 ± 1.41b	5.6 ± 1.65b	5.6 ± 1.67b
4	Negative phage		12	8.36 ± 1.46	4.84 ± 0.93	4.75 ± 1.06
	ABC 1	Peptide 1	12	7.35 ± 1.8c	4.21 ± 1.38b	3.65 ± 0.84c
	ABC 2	Peptide 1	12	6.9 ± 1.01c	3.8 ± 0.96c	3.19 ± 0.50c
	ABC 4	Peptide 2	12	6.82 ± 1.00c	3.47 ± 1.09c	3.75 ± 0.92c
	ABC 5	Peptide 2	12	7.23 ± 1.25c	4.25 ± 1.25b	4.25 ± 1.34b
5	Negative phage		10	8.45 ± 2.58	4.98 ± 1.14	4.32 ± 1.41
	ABC 4	Peptide 2	10	6.86 ± 0.94c	3.88 ± 0.91c	3.82 ± 0.80b

^aThe phage dose was 10^9±0.5 PFU. Mice were culled at 24 h in experiment 1 but at 48 h for all following experiments. 

^bSemilogarithmic reduction compared to negative control. 

^cLogarithmic reduction compared to negative control.