Table 4. Univariate and multivariate analyses of major amputations among inpatients treated for PAOD (2016–2018).
| Major amputations | Univariate analysis |
Multivariate analysis
(Nagelkerke’s pseudo-R²: 0.270) |
||
| Odds ratio | p-value | Odds ratio | p-value | |
| PAOD stage − Fontaine IIb (ref) − Fontaine III − Fontaine IVu − Fontaine IVg |
1.00 44.82 [35.81; 56.09] 81.63 [65.62; 101.54] 518.97 [418.25; 643.94] |
< 0.001 < 0.001 < 0.001 |
1.00 45.09 [36.03; 56.44] 84.24 [67.70; 104.82] 526.09 [423.81; 653.06] |
< 0.001 < 0.001 < 0.001 |
| Age (continuous) | 1.03 [1.03; 1.03] | < 0.001 | 1.00 [0.99; 1.00] | < 0.001 |
| Sex − male (ref) − female |
1.00 0.94 [0.92; 0.97] |
< 0.001 |
1.00 0.96 [0.93; 0.99] |
0.012 |
| Hypertension | 0.73 [0.71; 0.76] | < 0.001 | 0.89 [0.87; 0.92] | < 0.001 |
| Type 2 diabetes mellitus | 1.48 [1.44; 1.53] | < 0.001 | 0.96 [0.93; 0.99] | 0.008 |
| Dyslipidemia | 0.58 [0.56; 0.60] | < 0.001 | 0.86 [0.83; 0.89] | < 0.001 |
| Care level − Maximum care (≥ 800) (ref) − Central care (500–799) − Standard care (300–499) − Basic care (100–299) − Minimum care (< 100) |
1.00 1.00 [0.96; 1.04] 0.98 [0.94; 1.02] 0.98 [0.94; 1.02] 0.68 [0.58; 0.80] |
0.979 0.348 0.360 < 0.001 |
1.00 1.02 [0.98; 1.06] 1.03 [0.99; 1.08] 1.00 [0.96; 1.05] 0.75 [0.64; 0.88] |
0.380 0.161 0.865 < 0.001 |
| Certification status − Not certified (ref) − Certified |
1.00 0.88 [0.86; 0.91] |
< 0.001 |
1.00 0.95 [0.92; 0.98] |
0.003 |
The odds ratios are given with their 95% confidence intervals. In the multivariate analysis they were adjusted for all variables (PAOD stage, age, sex, hypertension, type 2 diabetes mellitus, dyslipidemia, care level, and certification status).
IVg, Stage IV with gangrene; IVu, stage IV with ulceration; ref, reference; PAOD, peripheral arterial occlusive disease