eTable. Quarterly multivariate analyses for in-hospital mortality and amputations among inpatients treated for PAOD.
| Quarter | 2016-2 | 2016-3 | 2017-2 | 2017-3 | 2018-2 | 2018-3 | ||||||
| Inpatient cases (n) | 48 445 | 47 311 | 47 023 | 47 046 | 47 852 | 45 955 | ||||||
| Odds ratio | p-value | Odds ratio | p-value | Odds ratio | p-value | Odds ratio | p-value | Odds ratio | p-value | Odds ratio | p-value | |
| In-hospital mortality | ||||||||||||
| PAOD stage III | 6.18 [4.47; 8.54] | < 2e, 16 | 8.04 [5.80; 11.16] | < 2e, 16 | 6.84 [4.75; 9.84] | < 2e, 16 | 8.42 [6.00; 11.81] | < 2e, 16 | 6.51 [4.66; 9.09] | < 2e, 16 | 7.96 [5.64; 11.23] | < 2e, 16 |
| pPAOD stage IVg | 20.06 [15.17; 26.53] |
< 2e, 16 | 25.69 [19.24; 34.30] |
< 2e, 16 | 25.26 [18.45; 34.57] |
< 2e, 16 | 26.66 [19.75. 35.98] |
< 2e, 16 | 20.30 [15.24; 27.04] |
< 2e, 16 | 24.46 [18.08; 33.08] |
< 2e, 16 |
| PAOD stage IVu | 9.44 [7.07; 12.60] | < 2e, 16 | 10.25 [7.60; 13.84] | < 2e, 16 | 10.80 [7.80; 14.95] | < 2e, 16 | 10.95 [8.03; 14.95] | < 2e, 16 | 9.36 [6.94; 12.60] | < 2e, 16 | 9.84 [7.18; 13.47] | < 2e, 16 |
| Age in years | 1.04 [1.03; 1.05] | < 2e, 16 | 1.04 [1.03; 1.05] | < 2e, 16 | 1.05 [1.04; 1.06] | < 2e, 16 | 1.05 [1.04; 1.05] | < 2e, 16 | 1.04 [1.03; 1.05] | < 2e, 16 | 1.04 [1.03; 1.05] | < 2e, 16 |
| Sex, female | 1.04 [0.92; 1.18] | 0.4892 | 0.98 [0.87; 1.11] | 0.7824 | 0.88 [0.78; 1.00] | 0.0493 | 0.96 [0.84; 1.09] | 0.5110 | 1.06 [0.93; 1.20] | 0.3892 | 0.92 [0.80; 1.05] | 0.2066 |
| Basic care | 0.87 [0.72; 1.06] | 0.1718 | 0.75 [0.62; 0.92] | 0.0052 | 0.86 [0.71; 1.04] | 0.1202 | 0.88 [0.72; 1.08] | 0.2101 | 0.67 [0.55; 0.81] | 0.0000 | 0.77 [0.62; 0.95] | 0.0155 |
| Minimum care | 0.43 [0.19; 0.98] | 0.0447 | 0.57 [0.28; 1.17] | 0.1245 | 0.55 [0.28; 1.10] | 0.0914 | 0.81 [0.43; 1.52] | 0.5163 | 0.56 [0.28; 1.10] | 0.0918 | 0.23 [0.07; 0.71] | 0.0114 |
| Standard care | 1.00 [0.84; 1.18] | 0.9908 | 1.10 [0.93; 1.30] | 0.2632 | 0.95 [0.80; 1.12] | 0.5175 | 0.96 [0.81; 1.15] | 0.6891 | 0.85 [0.72; 1.00] | 0.0569 | 1.03 [0.86; 1.24] | 0.7431 |
| Central care | 1.03 [0.87; 1.21] | 0.7674 | 0.95 [0.80; 1.13] | 0.5838 | 1.02 [0.86; 1.21] | 0.7956 | 1.13 [0.95; 1.35] | 0.1558 | 0.87 [0.73; 1.03] | 0.1022 | 1.04 [0.86; 1.25] | 0.7004 |
| Certified | 0.98 [0.86; 1.13] | 0.8076 | 1.00 [0.87; 1.14] | 0.9472 | 0.93 [0.81; 1.06] | 0.2856 | 1.16 [1.01; 1.33] | 0.0324 | 0.87 [0.76; 1.00] | 0.0567 | 0.93 [0.81; 1.08] | 0.3650 |
| Hypertension | 0.55 [0.49; 0.62] | < 2e, 16 | 0.66 [0.58; 0.74] | 0.0000 | 0.72 [0.64; 0.81] | 0.0000 | 0.64 [0.57; 0.73] | 0.0000 | 0.65 [0.58; 0.74] | 0.0000 | 0.74 [0.64; 0.84] | 0.0000 |
| Type 2 diabetes mellitus | 1.06 [0.94; 1.20] | 0.3134 | 0.98 [0.87; 1.11] | 0.7871 | 1.18 [1.04; 1.33] | 0.0078 | 0.97 [0.85; 1.10] | 0.5905 | 0.99 [0.87; 1.12] | 0.8616 | 1.00 [0.88; 1.15] | 0.9713 |
| Dyslipidemia | 0.66 [0.57; 0.76] | 0.0000 | 0.69 [0.60; 0.79] | 0.0000 | 0.78 [0.68; 0.90] | 0.0004 | 0.69 [0.60; 0.80] | 0.0000 | 0.66 [0.57; 0.76] | 0.0000 | 0.62 [0.53; 0.72] | 0.0000 |
| Nagelkerke’s pseudo-R² | 0.17067153 | 0.1796869 | 0.17626055 | 0.1887138 | 0.1648561 | 0.17367796 | ||||||
| Major amputations | ||||||||||||
| PAOD stage III | 28.80 [14.89; 55.71] |
< 2e, 16 | 62.28 [27.26; 142.29] |
< 2e, 16 | 40.97 [19.82; 84.68] |
< 2e, 16 | 30.02 [15.49; 58.19] |
< 2e, 16 | 38.58 [18.61; 80.01] |
< 2e, 16 | 72.57 [26.45; 199.14] |
< 2e, 16 |
| pPAOD stage IVg | 372.41 [199.49; 695.22] |
< 2e, 16 | 746.30 [334.30; 1666.09] | < 2e, 16 | 442.74 [220.55; 888.79] | < 2e, 16 | 432.01 [231.40; 806.54] | < 2e, 16 | 460.26 [229.27; 923.97] | < 2e, 16 | 1002.32 [374.98; 2679.18] | < 2e, 16 |
| PAOD stage IVu | 62.36 [33.10; 117.48] |
< 2e, 16 | 116.48 [51.82; 261.82] | < 2e, 16 | 69.93 [34.49; 141.76] | < 2e, 16 | 65.23 [34.59; 123.00] | < 2e, 16 | 74.72 [36.87; 151.41] | < 2e, 16 | 165.64 [61.58; 445.49] | < 2e, 16 |
| Age in years | 1.00 [0.99; 1.00] | 0.2148 | 0.99 [0.99; 1.00] | 0.0314 | 1.00 [0.99; 1.00] | 0.0469 | 1.00 [0.99; 1.00] | 0.1972 | 1.00 [0.99; 1.00] | 0.0576 | 0.99 [0.99; 1.00] | 0.0344 |
| Sex, female | 0.97 [0.87; 1.08] | 0.5727 | 1.03 [0.93; 1.15] | 0.5858 | 0.92 [0.83; 1.03] | 0.1547 | 0.98 [0.88; 1.09] | 0.6960 | 0.89 [0.80; 0.99] | 0.0398 | 0.95 [0.84; 1.07] | 0.3904 |
| Basic care | 1.16 [0.98; 1.36] | 0.0773 | 0.96 [0.82; 1.13] | 0.6116 | 1.19 [1.01; 1.40] | 0.0407 | 1.06 [0.90; 1.25] | 0.4826 | 0.97 [0.82; 1.15] | 0.7329 | 1.09 [0.91; 1.29] | 0.3408 |
| Minimum care | 0.75 [0.41; 1.38] | 0.3552 | 0.80 [0.47; 1.37] | 0.4171 | 0.83 [0.49; 1.41] | 0.4937 | 1.00 [0.61; 1.66] | 0.9848 | 0.85 [0.49; 1.50] | 0.5858 | 0.67 [0.36; 1.26] | 0.2112 |
| Standard care | 1.10 [0.95; 1.28] | 0.1948 | 0.92 [0.80; 1.06] | 0.2683 | 1.12 [0.97; 1.30] | 0.1255 | 1.06 [0.91; 1.23] | 0.4601 | 1.05 [0.91; 1.21] | 0.5207 | 1.11 [0.95; 1.30] | 0.1870 |
| Central care | 1.00 [0.86; 1.16] | 0.9876 | 0.98 [0.85; 1.13] | 0.8002 | 1.15 [0.99; 1.34] | 0.0679 | 1.02 [0.88; 1.19] | 0.7992 | 1.14 [0.99; 1.32] | 0.0770 | 1.15 [0.98; 1.34] | 0.0809 |
| Certified | 0.97 [0.86; 1.09] | 0.5887 | 0.96 [0.85; 1.08] | 0.4909 | 0.94 [0.83; 1.05] | 0.2788 | 0.89 [0.79; 1.00] | 0.0516 | 0.97 [0.86; 1.09] | 0.5859 | 0.99 [0.90; 1.10] | 0.7796 |
| Hypertension | 0.81 [0.73; 0.89] | 0.0000 | 0.96 [0.86; 1.06] | 0.4171 | 0.85 [0.76; 0.94] | 0.0021 | 0.87 [0.79; 0.97] | 0.0145 | 1.00 [0.90; 1.11] | 0.9705 | 0.96 [0.85; 1.07] | 0.4438 |
| Type 2 diabetes mellitus | 0.96 [0.86; 1.06] | 0.3869 | 0.95 [0.86; 1.05] | 0.3148 | 0.94 [0.85; 1.05] | 0.2644 | 0.95 [0.86; 1.06] | 0.3477 | 0.91 [0.82; 1.01] | 0.0886 | 0.90 [0.81; 1.01] | 0.0667 |
| Dyslipidemia | 0.86 [0.77; 0.97] | 0.0118 | 0.89 [0.79; 0.99] | 0.0359 | 0.95 [0.85; 1.06] | 0.3476 | 0.85 [0.76; 0.96] | 0.0068 | 0.89 [0.80; 1.00] | 0.0482 | 0.81 [0.72; 0.91] | 0.0004 |
| Nagelkerke’s pseudo-R² | 0.27059174 | 0.28977066 | 0.26567701 | 0.29268269 | 0.26752094 | 0.28769807 | ||||||
| Minor amputations | ||||||||||||
| PAOD stage III | 10.35 [4.05; 26.44] | 0.0000 | 9.82 [4.49; 21.44] | 0.0000 | 8.34 [3.77; 18.46] | 0.0000 | 10.07 [4.81; 21.08] | 0.0000 | 6.62 [2.74; 15.98] | 0.0000 | 4.04 [1.78; 9.16] | 0.0008 |
| pPAOD stage IVg | 1763.30 [791.05; 3930.52] |
< 2e, 16 | 1312.51 [681.16; 2529.03] |
< 2e, 16 | 1140.29 [591.96; 2196.57] |
< 2e, 16 | 1098.17 [589.32; 2046.37] |
< 2e, 16 | 1360.36 [678.92; 2725.75] |
< 2e, 16 | 929.41 [526.20; 1641.58] |
< 2e, 16 |
| PAOD stage IVu | 312.11 [139.70; 697.32] |
< 2e, 16 | 241.18 [124.87; 465.85] |
< 2e, 16 | 205.09 [106.15; 396.23] |
< 2e, 16 | 197.33 [105.58; 368.82] |
< 2e, 16 | 241.75 [120.33; 485.69] |
< 2e, 16 | 167.96 [94.79; 297.61] |
< 2e, 16 |
| Age in years | 1.00 [0.99; 1.00] | 0.1559 | 1.00 [0.99; 1.00] | 0.0781 | 1.00 [1.00; 1.00] | 0.6729 | 1.00 [0.99; 1.00] | 0.4985 | 1.00 [1.00; 1.00] | 0.4372 | 1.00 [0.99; 1.00] | 0.5178 |
| Sex, female | 0.60 [0.56; 0.66] | < 2e, 16 | 0.55 [0.51; 0.60] | < 2e, 16 | 0.57 [0.52; 0.62] | < 2e, 16 | 0.60 [0.55; 0.65] | < 2e, 16 | 0.59 [0.54; 0.64] | < 2e, 16 | 0.59 [0.54; 0.65] | < 2e, 16 |
| Basic care | 0.98 [0.87; 1.11] | 0.7561 | 1.05 [0.93; 1.19] | 0.4062 | 1.04 [0.93; 1.18] | 0.4746 | 0.89 [0.78; 1.01] | 0.0686 | 0.95 [0.85; 1.07] | 0.3867 | 0.96 [0.85; 1.09] | 0.5680 |
| Minimum care | 0.74 [0.48; 1.15] | 0.1810 | 0.60 [0.38; 0.95] | 0.0276 | 0.66 [0.45; 0.98] | 0.0408 | 0.52 [0.33; 0.82] | 0.0051 | 0.59 [0.38; 0.90] | 0.0154 | 0.63 [0.41; 0.97] | 0.0376 |
| Standard care | 1.10 [0.99; 1.22] | 0.0861 | 1.18 [1.06; 1.32] | 0.0026 | 1.10 [0.99; 1.22] | 0.0804 | 1.01 [0.90; 1.13] | 0.8585 | 1.02 [0.92; 1.13] | 0.7614 | 1.04 [0.93; 1.17] | 0.4849 |
| Central care | 1.10 [0.99; 1.23] | 0.0755 | 1.06 [0.95; 1.18] | 0.3125 | 1.11 [1.00; 1.24] | 0.0472 | 1.00 [0.89; 1.12] | 0.9937 | 0.99 [0.89; 1.10] | 0.8786 | 1.08 [0.96; 1.21] | 0.2012 |
| Certified | 1.07 [0.98; 1.16] | 0.1479 | 1.05 [0.96; 1.14] | 0.3006 | 1.04 [0.95; 1.13] | 0.3908 | 1.03 [0.94; 1.12] | 0.5556 | 1.05 [0.96; 1.14] | 0.2903 | 1.03 [0.94; 1.13] | 0.5022 |
| Hypertension | 1.03 [0.95; 1.11] | 0.4997 | 1.03 [0.95; 1.12] | 0.4075 | 1.05 [0.97; 1.14] | 0.2164 | 1.00 [0.92; 1.09] | 0.9792 | 1.09 [1.01; 1.18] | 0.0342 | 1.07 [0.99; 1.17] | 0.1025 |
| Type 2 diabetes mellitus | 1.37 [1.27; 1.47] | 0.0000 | 1.33 [1.23; 1.44] | 0.0000 | 1.22 [1.13; 1.31] | 0.0000 | 1.43 [1.32; 1.55] | < 2e, 16 | 1.33 [1.24; 1.43] | 0.0000 | 1.46 [1.35; 1.59] | < 2e, 16 |
| Dyslipidemia | 0.99 [0.91; 1.08] | 0.8381 | 1.04 [0.96; 1.13] | 0.3079 | 0.96 [0.88; 1.04] | 0.2926 | 0.97 [0.89; 1.06] | 0.4950 | 0.99 [0.92; 1.07] | 0.8060 | 1.04 [0.96; 1.13] | 0.3611 |
| Nagelkerke’s pseudo-R² | 0.4174419 | 0.4271354 | 0.4117935 | 0.4245308 | 0.4221647 | 0.4324692 | ||||||
The PAOD stages corrrespond to the Fontaine classification. The odds ratios are given with their 95% confidence intervals. They were adjusted for all variables (PAOD stage, age, sex, hypertension, type 2 diabetes mellitus, dyslipidemia, care level, and certification status).
IVg, Stage IV with gangrene; IVu, stage IV with ulceration; PAOD, peripheral arterial occlusive disease