Table 2. Putative KLK6 Substrates and Cleavage Sites Identified in the HUNTER Analysis of Capan-2 Conditioned Media^a.

gene	protein name	P4–P1	peptide ID	cleavage position (P1′)	Log2(H/L ratio)
ACT/POTE	actin/POTE	DAPR	AVFPSIVGRPR	29	–0.60
ALDOA	fructose–bisphosphate aldolase A	IAHR	IVAPGKGILAADESTGSIAKR	23	–0.76
C22orf42	uncharacterized protein C22orf42	ARSR	LNEPISSQVLGLLR	237	–1.36
CST3	cystatin-C	KPPR	LVGGPMDASVEEEGVRR	35	–1.26
CST3	cystatin-C	KPPR	LVGGPMDASVEEEGVR	35	–1.41
EIF4A1	eukaryotic initiation factor 4A-I	EVQK	LQMEAPHIIVGTPGR	147	–1.38
EPS8	epidermal growth factor receptor kinase substrate 8	DALR	MISNADPSIPPPPR	201	–1.55
FGFBP1	fibroblast growthfactor-bindingprotein 1	SSLK	LVSSTLFGNTKPR	150	–0.92
FLNA	filamin-A	VKAR	VANPSGNLTETYVQDR	1297	–1.21
FLNB	filamin-B	APLK	IFAQDGEGQR	513	–1.01
GNG12	guanine nucleotide-binding protein subunit gamma-12	-SSK	TASTNNIAQAR	5	–1.30
HSP90A	heat shock protein HSP 90-beta	DPSK	LDSGKELKIDIIPNPQER	65	–0.85
HSPA 1A/1B/6	heat shock 70 kDa protein 1A/1B/6	NVLR	IINEPTAAAIAYGLDR	117	–1.10
HSPA8	heat shock cognate 71 kDa protein	NVLR	IINEPTAAAIAYGLDKKVGAER	172	–0.92
HSPA8	heat shock cognate 71 kDa protein	DTER	LIGDAAKNQVAMNPTNTVFDAKR	50	–1.14
HSPG2	heparan sulfate proteoglycan 2	GEAR	LVSEDPINDGEWHR	4282	–0.71
KLK10	kallikrein-10	MLLK	LARPVVLGPR	143	–1.11
KLK6	kallikrein-6	LRQR	ESSQEQSSVVR	81	–2.01
KLK6	kallikrein-6	RPAK	LSELIQPLPLER	118	–1.51
KLK6	kallikrein-6	HNLR	QRESSQEQSSVVR	79	–1.14
LAMC2	laminin subunit gamma-2	SVSR	LQGVSDQSFQVEEAKR	858	–0.90
LOXL4	lysyl oxidase homolog 4	TKLR	LVGPESKPEEGR	34	–1.29
NME 1/2	nucleoside diphosphate kinase A/B	NCER	TFIAIKPDGVQR	7	–1.03
PCDH1	protocadherin-1	HLYK	LEVGAPYLR	92	–0.68
PLAT	tissue-type plasminogen activator	RGAR	SYQGCSEPR	36	–1.38
PLEC	plectin	GVAR	LSAEAEKVLALPEPSPAAPTLR	1066	–1.18
RARRES1	retinoic acid receptor responder protein 1	SALR	VLAEVQEGR	82	–1.24
ST14	matriptase	TVQR	TQDNSCSFGLHAR	209	–0.92
TKT	transketolase	DQQK	LQALKDTANR	12	–0.57

^aSites of particular interest are highlighted in bold.