Table 1.
Sample characteristics of ADNI participants with available serum creatinine, plasma, and CSF NfL data
| Variables | Mean (SD) | ||
|---|---|---|---|
| Everyone (N = 393) | Male (N = 236) | Female (N = 157) | |
| Age | 75.22 (6.35) | 75.68 (6.39) | 74.53 (6.25) |
| Years of education | 15.86 (2.96) | 16.41 (2.86) | 15.03 (2.92) |
| Body mass index+ | 26.24 (3.99) | 26.45 (3.56) | 25.92 (4.56) |
| Estimated glomerular filtration rate (eGFR)+ (mL/min/1.73 m2) | 69.77 (14.80) | 68.79 (14.85) | 71.25 (14.65) |
| Serum creatinine (mg/dL) | 0.98 (0.24) | 1.08 (0.23) | 0.83 (0.17) |
| Plasma NfL* (ng/L) | 38.94 (26.02) | 39.17 (25.58) | 38.58 (26.75) |
| CSF NfL^ (pg/mL) | 1387.13 (1037.74) | 1497.93 (1142.21) | 1216.67 (828.48) |
| Race/ethnicity | |||
| % White/non-Hispanic | 93% (367) | 94% (222) | 92% (145) |
| % others | 7% (26) | 6% (14) | 8% (12) |
| Mild cognitive impairment | |||
| % yes | 51% (200) | 56% (132) | 43% (68) |
| % no | 49% (193) | 44% (104) | 57% (89) |
Non-residualized scores reported for biomarkers
*Seven missing (2 males, 5 females) (N = 386)
+Two missing (1 male, 1 female) (N = 391)
^Ninety-six missing (56 males, 40 females) (N = 297)