Table 3.

Correlations of plasma NfL with brain structural measures in the ADNI and VETSA samples

ADNI—brain structures	Plasma NfL	p value	Plasma NfL adjusted	p value
Hippocampal volume	− 0.21 [− 0.31, − 0.11]	< 0.001	− 0.18 [− 0.28, − 0.07]	< 0.001
Medial temporal lobe volume	− 0.12 [− 0.23, − 0.01]	0.033	− 0.11 [− 0.23, − 0.00]	0.047
Whole brain volume	− 0.22 [− 0.32, − 0.12]	< 0.001	− 0.21 [− 0.30, − 0.11]	< 0.001
VETSA—brain structures	Plasma NfL	p value	Plasma NfL adjusted	p value
Hippocampal volume	− 0.04 [− 0.15, 0.06]	> 0.05	− 0.03 [− 0.14, 0.07]	> 0.05
Medial temporal lobe volume	0.07 [− 0.03, 0.17]	> 0.05	0.05 [− 0.05, 0.15]	> 0.05
Whole brain volume	0.01 [− 0.09, 0.11]	> 0.05	0.02 [− 0.08, 0.11]	> 0.05

Correlations of plasma NfL are shown with and without adjusting for creatinine. Structural measures were adjusted for age, sex when applicable, and intracranial volume