Table 2.

Basic information of candidate SNPs CYP19A1

SNP ID	Chr	Position	Alleles A/B	MAF		p-HWE†	Heterozygosity	p‡	OR (95%CI)	HaploReg	RegulomeDB
				Case	Control
rs28757157	Chr15	51,253,204	T/C	0.215	0.174	0.144	0.309	0.025	1.30 (1.03–1.64)	Enhancer histone marks, motifs changed, selected eQTL hits	TF binding + DNase peak
rs3751592	Chr15	51,314,381	C/T	0.133	0.112	0.999	0.199	0.172	1.21 (0.92–1.59)	Promoter histone marks, enhancer histone marks, DNAse, motifs changed, selected eQTL hits	TF binding + DNase peak
rs3751591	Chr15	51,314,513	G/A	0.137	0.133	0.840	0.235	0.798	1.04 (0.80–1.35)	Promoter histone marks, enhancer histone marks, DNAse, motifs changed	TF binding + DNase peak
rs59429575	Chr15	51,314,880	T/C	0.172	0.139	0.248	0.228	0.052	1.28 (1.00–1.64)	Promoter histone marks, enhancer histone marks, DNAse, proteins bound, motifs changed	TF binding or DNase peak

SNP single-nucleotide polymorphism, MAF minor allele frequency, OR odds ratio, 95%CI 95% confidence interval

Bold values indicate statistical significance (p < 0.05)

^†HWE p values were calculated from two-sided χ² test

^‡p values were calculated from two-sided χ² test