Table 3.
Analysis of the association between CYP19A1 polymorphisms and risk of lung cancer
| SNP ID | Model | Genotype | Control | Case | Crude | Adjusted | ||
|---|---|---|---|---|---|---|---|---|
| OR (95%CI) | p | OR (95%CI) | p | |||||
| rs28757157 | Genotype | C/C | 313 (67.2%) | 276 (59%) | 1 | 0.030 | 1 | 0.034 |
| T/C | 144 (30.9%) | 183 (39.1%) | 1.44 (1.10–1.89) | 1.43 (1.09–1.88) | ||||
| T/T | 9 (1.9%) | 9 (1.9%) | 1.13 (0.44–2.90) | 1.09 (0.42–2.79) | ||||
| Dominant | C/C | 313 (67.2%) | 276 (59%) | 1 | 0.009 | 1 | 0.011 | |
| T/C-T/T | 153 (32.8%) | 192 (41%) | 1.42 (1.09–1.86) | 1.41 (1.08–1.85) | ||||
| Recessive | C/C-T/C | 457 (98.1%) | 459 (98.1%) | 1 | 0.990 | 1 | 0.910 | |
| T/T | 9 (1.9%) | 9 (1.9%) | 1.00 (0.39–2.53) | 0.95 (0.37–2.43) | ||||
| Additive | –- | –- | –- | 1.35 (1.05–1.72) | 0.017 | 1.34 (1.04–1.71) | 0.021 | |
| rs3751592 | Genotype | T/T | 368 (78.8%) | 374 (76.5%) | 1 | 0.150 | 1 | 0.170 |
| C/T | 93 (19.9%) | 100 (20.4%) | 1.06 (0.77–1.45) | 1.06 (0.77–1.45) | ||||
| C/C | 6 (1.3%) | 15 (3.1%) | 2.46 (0.94–6.41) | 2.40 (0.92–6.27) | ||||
| Dominant | T/T | 368 (78.8%) | 374 (76.5%) | 1 | 0.390 | 1 | 0.400 | |
| C/T-C/C | 99 (21.2%) | 115 (23.5%) | 1.14 (0.84–1.55) | 1.14 (0.84–1.55) | ||||
| Recessive | T/T-C/T | 461 (98.7%) | 474 (96.9%) | 1 | 0.056 | 1 | 0.064 | |
| C/C | 6 (1.3%) | 15 (3.1%) | 2.43 (0.94–6.32) | 2.37 (0.91–6.18) | ||||
| Additive | –- | –- | –- | 1.20 (0.92–1.56) | 0.180 | 1.19 (0.91–1.56) | 0.200 | |
| rs3751591 | Genotype | A/A | 348 (75%) | 364 (74.7%) | 1 | 0.820 | 1 | 0.800 |
| G/A | 109 (23.5%) | 113 (23.2%) | 0.99 (0.73–1.34) | 0.99 (0.73–1.34) | ||||
| G/G | 7 (1.5%) | 10 (2%) | 1.37 (0.51–3.63) | 1.38 (0.52–3.69) | ||||
| Dominant | A/A | 348 (75%) | 364 (74.7%) | 1 | 0.930 | 1 | 0.920 | |
| G/A-G/G | 116 (25%) | 123 (25.3%) | 1.01 (0.76–1.36) | 1.02 (0.76–1.36) | ||||
| Recessive | A/A-G/A | 457 (98.5%) | 477 (98%) | 1 | 0.520 | 1 | 0.510 | |
| G/G | 7 (1.5%) | 10 (2%) | 1.37 (0.52–3.63) | 1.39 (0.52–3.69) | ||||
| Additive | –- | –- | –- | 1.04 (0.80–1.35) | 0.800 | 1.04 (0.80–1.35) | 0.790 | |
| rs59429575 | Genotype | C/C | 348 (74.7%) | 345 (70.5%) | 1 | 0.110 | 1 | 0.120 |
| T/C | 106 (22.8%) | 120 (24.5%) | 1.14 (0.85–1.54) | 1.14 (0.85–1.55) | ||||
| T/T | 12 (2.6%) | 24 (4.9%) | 2.02 (0.99–4.10) | 1.99 (0.98–4.05) | ||||
| Dominant | C/C | 348 (74.7%) | 345 (70.5%) | 1 | 0.150 | 1 | 0.150 | |
| T/C-T/T | 118 (25.3%) | 144 (29.4%) | 1.23 (0.93–1.64) | 1.23 (0.92–1.64) | ||||
| Recessive | C/C-T/C | 454 (97.4%) | 465 (95.1%) | 1 | 0.056 | 1 | 0.061 | |
| T/T | 12 (2.6%) | 24 (4.9%) | 1.95 (0.96–3.95) | 1.93 (0.95–3.91) | ||||
| Additive | –- | –- | –- | 1.25 (0.99–1.59) | 0.063 | 1.25 (0.98–1.59) | 0.066 | |
p values were calculated from logistic regression without and with adjustments for age, gender, BMI, smoking, and drinking
Bold values indicate statistical significance (p < 0.05)