Table 4.
Stratification analyses by demographic characteristics for the association between CYP19A1 polymorphisms and the risk of lung cancer
| Group/SNPs | Model | Genotype | Control | Case | OR (95%CI) | p | Control | Case | OR (95%CI) | p |
|---|---|---|---|---|---|---|---|---|---|---|
| Age, years | > 60 | ≤ 60 | ||||||||
| rs28757157 | Genotype | C/C | 172 (65.2%) | 156 (60.5%) | 1 | 0.490 | 141 (69.8%) | 120 (57.1%) | 1 | 0.018 |
| T/C | 84 (31.8%) | 94 (36.4%) | 1.25 (0.86–1.82) | 60 (29.7%) | 89 (42.4%) | 1.83 (1.20–2.79) | ||||
| T/T | 8 (3%) | 8 (3.1%) | 1.11 (0.39–3.10) | 1 (0.5%) | 1 (0.5%) | 1.37 (0.08–22.91) | ||||
| Dominant | C/C | 172 (65.2%) | 156 (60.5%) | 1 | 0.240 | 141 (69.8%) | 120 (57.1%) | 1 | 0.005 | |
| T/C-T/T | 92 (34.9%) | 102 (39.5%) | 1.24 (0.86–1.79) | 61 (30.2%) | 90 (42.9%) | 1.82 (1.20–2.77) | ||||
| Recessive | C/C-T/C | 256 (97%) | 250 (96.9%) | 1 | 0.970 | 201 (99.5%) | 209 (99.5%) | 1 | 0.960 | |
| T/T | 8 (3%) | 8 (3.1%) | 1.02 (0.37–2.83) | 1 (0.5%) | 1 (0.5%) | 1.08 (0.07–17.89) | ||||
| Log-additive | –- | –- | –- | 1.18 (0.86–1.63) | 0.300 | –- | –- | 1.78 (1.18–2.68) | 0.006 | |
| rs3751592 | Genotype | T/T | 198 (74.7%) | 210 (77.5%) | 1 | 0.068 | 170 (84.2%) | 164 (75.2%) | 1 | 0.032 |
| C/T | 63 (23.8%) | 51 (18.8%) | 0.73 (0.47–1.12) | 30 (14.8%) | 49 (22.5%) | 1.87 (1.12–3.15) | ||||
| C/C | 4 (1.5%) | 10 (3.7%) | 2.65 (0.80–8.73) | 2 (1%) | 5 (2.3%) | 2.66 (0.50–14.21) | ||||
| Dominant | T/T | 198 (74.7%) | 210 (77.5%) | 1 | 0.390 | 170 (84.2%) | 164 (75.2%) | 1 | 0.010 | |
| C/T-C/C | 67 (25.3%) | 61 (22.5%) | 0.84 (0.56–1.26) | 32 (15.8%) | 54 (24.8%) | 1.93 (1.16–3.19) | ||||
| Recessive | T/T-C/T | 261 (98.5%) | 261 (96.3%) | 1 | 0.071 | 200 (99%) | 213 (97.7%) | 1 | 0.290 | |
| C/C | 4 (1.5%) | 10 (3.7%) | 2.83 (0.86–9.30) | 2 (1%) | 5 (2.3%) | 2.35 (0.44–12.51) | ||||
| Log-additive | –- | –- | –- | 0.97 (0.69–1.38) | 0.870 | –- | –- | 1.81 (1.15–2.86) | 0.009 | |
| rs59429575 | Genotype | C/C | 190 (72%) | 196 (72.3%) | 1 | 0.260 | 158 (78.2%) | 149 (68.3%) | 1 | 0.047 |
| T/C | 68 (25.8%) | 62 (22.9%) | 0.86 (0.57–1.30) | 38 (18.8%) | 58 (26.6%) | 1.71 (1.06–2.76) | ||||
| T/T | 6 (2.3%) | 13 (4.8%) | 2.00 (0.73–5.50) | 6 (3%) | 11 (5%) | 1.99 (0.71–5.64) | ||||
| Dominant | C/C | 190 (72%) | 196 (72.3%) | 1 | 0.820 | 158 (78.2%) | 149 (68.3%) | 1 | 0.014 | |
| T/C-T/T | 74 (28%) | 75 (27.7%) | 0.96 (0.65–1.41) | 44 (21.8%) | 69 (31.6%) | 1.75 (1.11–2.75) | ||||
| Recessive | C/C-T/C | 258 (97.7%) | 258 (95.2%) | 1 | 0.140 | 196 (97%) | 207 (95%) | 1 | 0.280 | |
| T/T | 6 (2.3%) | 13 (4.8%) | 2.08 (0.76–5.67) | 6 (3%) | 11 (5%) | 1.75 (0.62–4.91) | ||||
| Log-additive | –- | –- | –- | 1.05 (0.76–1.46) | 0.760 | –- | –- | 1.57 (1.08–2.29) | 0.016 | |
| Gender | Males | Females | ||||||||
| rs28757157 | Genotype | C/C | 213 (65.5%) | 192 (60.2%) | 1 | 0.280 | 100 (70.9%) | 84 (56.4%) | 1 | 0.100 |
| T/C | 104 (32%) | 120 (37.6%) | 1.30 (0.93–1.81) | 40 (28.4%) | 63 (42.3%) | 1.75 (1.03–2.97) | ||||
| T/T | 8 (2.5%) | 7 (2.2%) | 0.91 (0.32–2.60) | 1 (0.7%) | 2 (1.3%) | 1.91 (0.17–21.86) | ||||
| Dominant | C/C | 213 (65.5%) | 192 (60.2%) | 1 | 0.150 | 100 (70.9%) | 84 (56.4%) | 1 | 0.033 | |
| T/C-T/T | 112 (34.5%) | 127 (39.8%) | 1.27 (0.92–1.76) | 41 (29.1%) | 65 (43.6%) | 1.76 (1.04–2.96) | ||||
| Recessive | C/C-T/C | 317 (97.5%) | 312 (97.8%) | 1 | 0.720 | 140 (99.3%) | 147 (98.7%) | 1 | 0.710 | |
| T/T | 8 (2.5%) | 7 (2.2%) | 0.83 (0.29–2.35) | 1 (0.7%) | 2 (1.3%) | 1.56 (0.14–17.69) | ||||
| Log-additive | –- | –- | –- | 1.20 (0.89–1.61) | 0.230 | –- | –- | 1.70 (1.03–2.80) | 0.036 | |
| Smoking | Yes | No | ||||||||
| rs28757157 | Genotype | C/C | 164 (69.8%) | 140 (59.8%) | 1 | 0.095 | 149 (64.5%) | 136 (58.1%) | 1 | 0.330 |
| T/C | 67 (28.5%) | 89 (38%) | 1.56 (1.04–2.34) | 77 (33.3%) | 94 (40.2%) | 1.35 (0.91–2.00) | ||||
| T/T | 4 (1.7%) | 5 (2.1%) | 1.37 (0.35–5.28) | 5 (2.2%) | 4 (1.7%) | 0.97 (0.24–3.90) | ||||
| Dominant | C/C | 164 (69.8%) | 140 (59.8%) | 1 | 0.031 | 149 (64.5%) | 136 (58.1%) | 1 | 0.150 | |
| T/C-T/T | 71 (30.2%) | 94 (40.2%) | 1.55 (1.04–2.30) | 82 (35.5%) | 98 (41.9%) | 1.33 (0.90–1.96) | ||||
| Recessive | C/C-T/C | 231 (98.3%) | 229 (97.9%) | 1 | 0.830 | 226 (97.8%) | 230 (98.3%) | 1 | 0.840 | |
| T/T | 4 (1.7%) | 5 (2.1%) | 1.16 (0.30–4.42) | 5 (2.2%) | 4 (1.7%) | 0.87 (0.22–3.45) | ||||
| Log-additive | –- | –- | –- | 1.46 (1.01–2.10) | 0.042 | –- | –- | 1.26 (0.88–1.80) | 0.210 | |
| Drinking | Yes | No | ||||||||
| rs28757157 | Genotype | C/C | 110 (73.8%) | 82 (60.7%) | 1 | 0.033 | 203 (64%) | 194 (58.3%) | 1 | 0.290 |
| T/C | 38 (25.5%) | 52 (38.5%) | 2.03 (1.18–3.50) | 106 (33.4%) | 131 (39.3%) | 1.29 (0.94–1.79) | ||||
| T/T | 1 (0.7%) | 1 (0.7%) | 2.46 (0.11–57.00) | 8 (2.5%) | 8 (2.4%) | 1.11 (0.41–3.06) | ||||
| Dominant | C/C | 110 (73.8%) | 82 (60.7%) | 1 | 0.009 | 203 (64%) | 194 (58.3%) | 1 | 0.120 | |
| T/C-T/T | 39 (26.2%) | 53 (39.3%) | 2.04 (1.18–3.51) | 114 (36%) | 139 (41.7%) | 1.28 (0.93–1.76) | ||||
| Recessive | C/C-T/C | 148 (99.3%) | 134 (99.3%) | 1 | 0.700 | 309 (97.5%) | 325 (97.6%) | 1 | 0.980 | |
| T/T | 1 (0.7%) | 1 (0.7%) | 1.85 (0.08–40.76) | 8 (2.5%) | 8 (2.4%) | 1.01 (0.37–2.76) | ||||
| Log-additive | –- | –- | –- | 1.99 (1.17–3.36) | 0.010 | –- | –- | 1.23 (0.92–1.63) | 0.160 | |
| rs3751592 | Genotype | T/T | 121 (80.7%) | 108 (75%) | 1 | 0.330 | 247 (77.9%) | 266 (77.1%) | 1 | 0.064 |
| C/T | 27 (18%) | 35 (24.3%) | 1.52 (0.83–2.79) | 66 (20.8%) | 65 (18.8%) | 0.89 (0.60–1.31) | ||||
| C/C | 2 (1.3%) | 1 (0.7%) | 0.52 (0.04–6.46) | 4 (1.3%) | 14 (4.1%) | 3.23 (1.04–9.97) | ||||
| Dominant | T/T | 121 (80.7%) | 108 (75%) | 1 | 0.220 | 247 (77.9%) | 266 (77.1%) | 1 | 0.910 | |
| C/T-C/C | 29 (19.3%) | 36 (25%) | 1.45 (0.80–2.62) | 70 (22.1%) | 79 (22.9%) | 1.02 (0.71–1.48) | ||||
| Recessive | T/T-C/T | 148 (98.7%) | 143 (99.3%) | 1 | 0.550 | 313 (98.7%) | 331 (95.9%) | 1 | 0.023 | |
| C/C | 2 (1.3%) | 1 (0.7%) | 0.47 (0.04–5.92) | 4 (1.3%) | 14 (4.1%) | 3.31 (1.07–10.19) | ||||
| Log-additive | –- | –- | –- | 1.33 (0.77–2.31) | 0.310 | –- | –- | 1.14 (0.83–1.56) | 0.410 | |
| rs59429575 | Genotype | C/C | 117 (78%) | 95 (66%) | 1 | 0.130 | 231 (73.1%) | 250 (72.5%) | 1 | 0.190 |
| T/C | 30 (20%) | 44 (30.6%) | 1.71 (0.97–3.02) | 76 (24.1%) | 76 (22%) | 0.90 (0.62–1.30) | ||||
| T/T | 3 (2%) | 5 (3.5%) | 2.18 (0.46–10.25) | 9 (2.8%) | 19 (5.5%) | 1.95 (0.86–4.41) | ||||
| Dominant | C/C | 117 (78%) | 95 (66%) | 1 | 0.044 | 231 (73.1%) | 250 (72.5%) | 1 | 0.960 | |
| T/C-T/T | 33 (22%) | 49 (34%) | 1.75 (1.01–3.03) | 85 (26.9%) | 95 (27.5%) | 1.01 (0.71–1.42) | ||||
| Recessive | C/C-T/C | 147 (98%) | 139 (96.5%) | 1 | 0.420 | 307 (97.2%) | 326 (94.5%) | 1 | 0.084 | |
| T/T | 3 (2%) | 5 (3.5%) | 1.87 (0.40–8.73) | 9 (2.8%) | 19 (5.5%) | 2.00 (0.89–4.51) | ||||
| Log-additive | –- | –- | –- | 1.63 (1.01–2.64) | 0.044 | –- | –- | 1.10 (0.83–1.46) | 0.500 | |
p values were calculated from logistic regression with adjustments for age, gender, BMI, smoking, and drinking
Bold values indicate statistical significance (p < 0.05)