Table 7.

SNP–SNP interaction models of CYP19A1 polymorphisms in lung cancer susceptibility

Model	Training Bal. Acc	Testing Bal. Acc	CVC	p
SNP-SNP interaction
rs28757157	0.5551	0.5503	10/10	0.0006
rs28757157, rs3751592	0.5620	0.5193	4/10	0.0002
rs28757157, rs3751592, rs3751591	0.5721	0.5428	9/10	< 0.0001
rs28757157, rs3751592, rs3751591, rs59429575	0.5827	0.5450	10/10	< 0.0001
CYP19A1 gene-environment interaction
rs28757157	0.555	0.550	10/10	0.0006
Gender, smoke	0.581	0.581	10/10	< 0.0001
Gender, BMI, smoke	0.593	0.560	5/10	< 0.0001
rs28757157, rs3751591, gender, smoke	0.608	0.532	5/10	< 0.0001
rs28757157, rs3751591, gender, BMI, smoke	0.636	0.601	9/10	< 0.0001
rs28757157, rs3751592, rs3751591, gender, BMI, smoke	0.658	0.560	4/10	< 0.0001
rs28757157, rs3751592, rs3751591, rs59429575, gender, BMI, smoke	0.685	0.558	8/10	< 0.0001

p values were calculated using χ² tests

Bold values indicate statistical significance (p < 0.05)