Table 1.
The relationships between the PINI and clinicopathological features of patients with colorectal cancer
| Features | Overall (n = 1304) | PINI | P value | |
|---|---|---|---|---|
| Low (n = 334) | High (n = 970) | |||
| Sex (Man) | 821 (63.0) | 236 (70.7) | 585 (60.3) | 0.001 |
| Age (mean (SD)) | 58.31 (13.00) | 61.26 (13.53) | 57.30 (12.66) | < 0.001 |
| Age (≥ 60) | 655 (50.2) | 205 (61.4) | 450 (46.4) | < 0.001 |
| BMI (median [IQR]) | 22.07 (20.00, 24.46) | 21.50 (19.15, 23.42) | 22.43 (20.21, 24.85) | < 0.001 |
| BMI | < 0.001 | |||
| Low (< 18.5) | 161 (12.3) | 64 (19.2) | 97 (10.0) | |
| Normal (18.5–24.9) | 762 (58.4) | 204 (61.1) | 558 (57.5) | |
| High (≥ 25) | 381 (29.2) | 66 (19.8) | 315 (32.5) | |
| Hypertension (Yes) | 218 (16.7) | 61 (18.3) | 157 (16.2) | 0.428 |
| Diabetes (Yes) | 82 (6.3) | 23 (6.9) | 59 (6.1) | 0.696 |
| T stage | 0.047 | |||
| T1 | 364 (27.9) | 88 (26.3) | 276 (28.5) | |
| T2 | 690 (52.9) | 181 (54.2) | 509 (52.5) | |
| T3 | 250 (19.2) | 65 (19.5) | 185 (19.1) | |
| N stage | 0.246 | |||
| N0 | 765 (58.7) | 204 (61.1) | 561 (57.8) | |
| N1 | 351 (26.9) | 91 (27.2) | 260 (26.8) | |
| N2 | 188 (14.4) | 39 (11.7) | 149 (15.4) | |
| TNM stage | 0.644 | |||
| Stage I | 284 (21.8) | 74 (22.2) | 210 (21.6) | |
| Stage II | 481 (36.9) | 129 (38.6) | 352 (36.3) | |
| Stage III | 539 (41.3) | 131 (39.2) | 408 (42.1) | |
| Perineural invasion (Yes) | 125 (9.6) | 30 (9.0) | 95 (9.8) | 0.744 |
| Vascular invasion (Yes) | 210 (16.1) | 46 (13.8) | 164 (16.9) | 0.208 |
| Macroscopic type | 0.011 | |||
| Protrude type | 376 (28.8) | 112 (33.5) | 264 (27.2) | |
| Infiltrating type | 99 (7.6) | 32 (9.6) | 67 (6.9) | |
| Ulcerative type | 829 (63.6) | 190 (56.9) | 639 (65.9) | |
| Differentiation (Poor) | 157 (12.0) | 44 (13.2) | 113 (11.6) | 0.522 |
| Tumor location (Rectal) | 685 (52.5) | 124 (37.1) | 561 (57.8) | < 0.001 |
| Tumor size (median [IQR]) | 4.50 (3.50, 6.00) | 5.50 (4.00, 7.50) | 4.00 (3.00, 5.00) | < 0.001 |
| CEA (High) | 497 (38.1) | 161 (48.2) | 336 (34.6) | < 0.001 |
| Surgical method (Endoscopic) | 796 (61.0) | 155 (46.4) | 641 (66.1) | < 0.001 |
| Operation time (median [IQR]) | 186.00 (148.00, 242.50) | 196.50 (163.25, 261.50) | 182.00 (143.00, 236.50) | < 0.001 |
| Intraoperative blood loss (median [IQR]) | 100.00 (50.00, 200.00) | 100.00 (80.00, 200.00) | 100.00 (50.00, 200.00) | < 0.001 |
| Radiotherapy (Yes) | 124 (9.5) | 17 (5.1) | 107 (11.0) | 0.002 |
| Chemotherapy (Yes) | 581 (44.6) | 138 (41.3) | 443 (45.7) | 0.183 |
| Death (Yes) | 457 (35.0) | 168 (50.3) | 289 (29.8) | < 0.001 |
| Hospital stays (median [IQR]) | 17.00 (11.00, 21.00) | 19.00 (15.00, 23.75) | 16.00 (10.00, 20.00) | < 0.001 |
| Hospitalization cost (median [IQR]) | 49239.24 (44407.25, 55607.16) | 51692.23 (45199.72, 59809.63) | 48729.73 (44257.75, 54564.84) | < 0.001 |
CRC Colorectal cancer, BMI Body mass index, PINI Prognostic immune and nutritional index