Table 2.

Association between PINI and disease-free survival of patients with colorectal cancer

PINI	Model a	P value	Model b	P value	Model c	P value
Continuous (per SD)	0.845 (0.784,0.912)	< 0.001	0.827 (0.763,0.897)	< 0.001	0.823 (0.754,0.898)	< 0.001
Cutoff value		< 0.001		< 0.001		< 0.001
C1 (~ 2.85)	ref		ref		ref
C2 (2.85~)	0.618 (0.513,0.743)		0.605 (0.500,0.733)		0.587 (0.477,0.722)
Quartiles
Q1 (~ 2.84)	ref		ref		ref
Q2 (2.84 ~ 3.15)	0.664 (0.526,0.84)	0.001	0.632 (0.498,0.802)	< 0.001	0.619 (0.484,0.793)	< 0.001
Q3 (3.15 ~ 3.38)	0.617 (0.484,0.786)	< 0.001	0.639 (0.498,0.819)	< 0.001	0.603 (0.464,0.783)	< 0.001
Q4 (3.38~)	0.582 (0.454,0.746)	< 0.001	0.558 (0.432,0.719)	< 0.001	0.542 (0.412,0.711)	< 0.001
p for trend		< 0.001		< 0.001		< 0.001

Model a: No adjusted

Model b: Adjusted for sex, age, T stage and N stage

Model c: Adjusted for sex, age, BMI, hypertension, diabetes, T stage, N stage, tumor location, tumor size, perineural invasion, vascular invasion, macroscopic type, differentiation, surgical approach, CEA level, radiotherapy, and chemotherapy