Table 3.

Association between PINI and overall survival of patients with colorectal cancer

PINI	Model a	P value	Model b	P value	Model c	P value
Continuous (per SD)	0.839 (0.777,0.906)	< 0.001	0.824 (0.759,0.895)	< 0.001	0.833 (0.761,0.912)	< 0.001
Cutoff value		< 0.001		< 0.001		< 0.001
C1 (~ 2.85)	ref		ref		ref
C2 (2.85~)	0.574 (0.474,0.694)		0.56 (0.459,0.682)		0.561 (0.453,0.696)
Quartiles
Q1 (~ 2.84)	ref		ref		ref
Q2 (2.84 ~ 3.15)	0.632 (0.496,0.805)	< 0.001	0.592 (0.463,0.757)	< 0.001	0.592 (0.458,0.765)	< 0.001
Q3 (3.15 ~ 3.38)	0.558 (0.432,0.72)	< 0.001	0.584 (0.45,0.759)	< 0.001	0.575 (0.436,0.757)	< 0.001
Q4 (3.38~)	0.547 (0.422,0.708)	< 0.001	0.523 (0.402,0.682)	< 0.001	0.534 (0.402,0.708)	< 0.001
p for trend		< 0.001		< 0.001		< 0.001

Model a: No adjusted

Model b: Adjusted for sex, age, T stage and N stage

Model c: Adjusted for sex, age, BMI, hypertension, diabetes, T stage, N stage, tumor location, tumor size, perineural invasion, vascular invasion, macroscopic type, differentiation, surgical approach, CEA level, radiotherapy, and chemotherapy