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. 2022 Dec 16;35(1):61–69. doi: 10.1016/j.sdentj.2022.12.002

Fig. 1.

Fig. 1

Quantification of bacterial proportions and mRNA expression of ACE2, as well as periodontitis-related inflammatory markers (TLR-2/TLR-4, TNFα, miR-155) in patients with periodontitis with (G1) and without diabetes (G2), diagnosed with COVID-19. (A) Value represents the relative proportion of Pg and Aa in G1 and G2. (B) Data represent the relative expression of ACE2 mRNA to control (patients with only periodontitis) that was set to 1. However, the relative transcription was not significant in either patient group (G1 or G2). (C) In both groups tested (G1 and G2), the transcription level of TLR-2 was lower than TLR-4. However, TLR-4 expression was higher in G1 than in G2 group. (D). Relative fold increases in expressions of TNFα mRNA and miR-155 are shown for G1 and G2. TNFα was up-regulated in G2, while miR-155 expression was accelerated in G1. All data are expressed as mean ± SE. * significant difference in gene expression within the group (G1 and G2). ** significant difference in gene expression between independent variables (TLR-2 and TLR-4). Pg = P. gingivalis. Aa = A. actinomycetemcomitans.