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. 2022 Jun 15;79(7):363. doi: 10.1007/s00018-022-04396-x

Fig. 1.

Fig. 1

TET genes and TET proteins. A TET1, TET2, and TET3 have 2, 3, and 3 transcriptional products, respectively, due to the use of alternative promoters, which are regulated by the alternative activation of enhancers. The green arrow indicates induction of expression; the red cross depicts inhibition of expression. B. The corresponding protein isoforms of TET1, TET2, and TET3. The structural domains of the proteins are indicated