Table 3:

Results of growth curve models of average inflammation as a predictor of cognitive score

	Model 1		Model 2		Model 3		Model 4		Model 5
	Beta	95% CI	Beta	95% CI	Beta	95% CI	Beta	95% CI	Beta	95% CI
Intercept
Baseline cognitive score, male	16.561	(16.206, 16.916)	16.167	(15.841, 16.492)	16.584	(16.153, 17.015)	16.112	(15.717, 16.507)	16.253	(15.669, 16.836)
Female	−1.309	(−1.842, −0.775)	−0.310	(−0.821, 0.201)	−1.258	(−1.835, −0.681)	−0.190	(−0.742, 0.361)	−0.038	(−0.572, 0.496)
Inflammation index, average	−0.621	(−0.915, −0.326)	−0.345	(−0.614, −0.076)	−0.593	(−0.894, −0.292)	−0.332	(−0.606, −0.057)	−0.310	(−0.576, −0.043)
Slope
Age * male	−0.169	(−0.212, −0.125)	−0.150	(−0.191, −0.110)	−0.169	(−0.214, −0.125)	−0.149	(−0.191, −0.108)	−0.139	(−0.179, −0.099)
Age * female	−0.278	(−0.328, −0.229)	−0.245	(−0.291, −0.199)	−0.278	(−0.328, −0.229)	−0.245	(−0.291, −0.199)	−0.227	(−0.272, −0.182)
Age * inflammation index, average	0.003	(−0.036, 0.042)	0.002	(−0.035, 0.038)	0.003	(−0.036, 0.042)	0.002	(−0.035, 0.038)	−0.004	(−0.039, 0.031)
SD(slope)	0.172	(0.129, 0.230)	0.165	(0.126, 0.216)	0.175	(0.132, 0.233)	0.167	(0.129, 0.218)	0.158	(0.120, 0.208)
SD(intercept)	2.559	(2.322, 2.822)	2.180	(1.951, 2.436)	2.546	(2.307, 2.808)	2.165	(1.936, 2.421)	2.053	(1.826, 2.307)
SD(residual)	2.217	(2.116, 2.323)	2.239	(2.137, 2.345)	2.216	(2.114, 2.322)	2.238	(2.136, 2.345)	2.250	(2.148, 2.357)
Includes education?	No		Yes		No		Yes		Yes
Includes BMI?	No		No		Yes		Yes		Yes
Includes current smoker?	No		No		Yes		Yes		Yes
Includes interviewer-rated heath?	No		No		No		No		Yes
Number of observations	1620		1620		1620		1620		1620
Number of respondents	596		596		596		596		596
Mean observations per respondent	2.7		2.7		2.7		2.7		2.7
Chi squared (p-value), sex * baseline cog score	23.092	(<0.001)	1.414	(0.234)	18.259	(<0.001)	0.458	(0.498)	0.019	(0.890)
Chi squared (p-value), sex * age	10.693	(0.001)	9.150	(0.002)	10.427	(0.001)	9.198	(0.002)	8.468	(0.004)