Table 4:
Results of growth curve models of average inflammation and change in inflammation as predictors of cognitive score
| Model 1 | Model 2 | Model 3 | Model 4 | Model 5 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Beta | 95% CI | Beta | 95% CI | Beta | 95% CI | Beta | 95% CI | Beta | 95% CI | |
|
|
||||||||||
| Intercept | ||||||||||
| Baseline cognitive score, male | 16.569 | (16.213, 16.925) | 16.179 | (15.854, 16.505) | 16.600 | (16.166, 17.035) | 16.139 | (15.741, 16.537) | 16.269 | (15.685, 16.853) |
| Female | −1.320 | (−1.857, −0.783) | −0.323 | (−0.835, 0.190) | −1.278 | (−1.859, −0.696) | −0.217 | (−0.771, 0.337) | −0.064 | (−0.600, 0.472) |
| Inflammation index, average | −0.620 | (−0.914, −0.325) | −0.341 | (−0.610, −0.072) | −0.591 | (−0.892, −0.289) | −0.325 | (−0.600, −0.050) | −0.303 | (−0.570, −0.037) |
| Inflammation index, change | 0.000 | (−0.308, 0.307) | 0.017 | (−0.259, 0.293) | −0.010 | (−0.317, 0.297) | 0.004 | (−0.271, 0.280) | 0.009 | (−0.258, 0.275) |
| Slope | ||||||||||
| Age * male | −0.168 | (−0.212, −0.124) | −0.149 | (−0.190, −0.108) | −0.169 | (−0.213, −0.124) | −0.148 | (−0.189, −0.107) | −0.137 | (−0.177, −0.097) |
| Age * female | −0.280 | (−0.330, −0.230) | −0.248 | (−0.294, −0.202) | −0.280 | (−0.330, −0.230) | −0.247 | (−0.294, −0.201) | −0.230 | (−0.276, −0.185) |
| Age * inflammation index, average | 0.003 | (−0.036, 0.042) | 0.000 | (−0.036, 0.037) | 0.002 | (−0.037, 0.041) | 0.000 | (−0.036, 0.037) | −0.005 | (−0.041, 0.030) |
| Age * inflammation index, change | −0.010 | (−0.049, 0.028) | −0.021 | (−0.057, 0.015) | −0.010 | (−0.049, 0.029) | −0.020 | (−0.056, 0.016) | −0.021 | (−0.056, 0.014) |
|
| ||||||||||
| SD(slope) | 0.173 | (0.129, 0.230) | 0.165 | (0.127, 0.216) | 0.176 | (0.133, 0.233) | 0.168 | (0.129, 0.218) | 0.158 | (0.120, 0.208) |
| SD(intercept) | 2.559 | (2.322, 2.821) | 2.178 | (1.950, 2.433) | 2.545 | (2.307, 2.807) | 2.163 | (1.934, 2.418) | 2.052 | (1.826, 2.306) |
| SD(residual) | 2.217 | (2.115, 2.323) | 2.238 | (2.136, 2.345) | 2.215 | (2.113, 2.321) | 2.237 | (2.135, 2.344) | 2.249 | (2.147, 2.356) |
|
| ||||||||||
| Includes education? | No | Yes | No | Yes | Yes | |||||
| Includes BMI? | No | No | Yes | Yes | Yes | |||||
| Includes current smoker? | No | No | Yes | Yes | Yes | |||||
| Includes interviewer-rated heath? | No | No | No | No | Yes | |||||
|
| ||||||||||
| Number of observations | 1620 | 1620 | 1620 | 1620 | 1620 | |||||
| Number of respondents | 596 | 596 | 596 | 596 | 596 | |||||
| Mean observations per respondent | 2.7 | 2.7 | 2.7 | 2.7 | 2.7 | |||||
|
| ||||||||||
| Chi squared (p-value), sex * baseline cog score | 23.227 | (<0.001) | 1.525 | (0.217) | 18.564 | (<0.001) | 0.590 | (0.442) | 0.055 | (0.815) |
| Chi squared (p-value), sex * age | 10.964 | (<0.001) | 9.898 | (0.002) | 10.716 | (0.001) | 9.894 | (0.002) | 9.224 | (0.002) |