Table 3.
Univariate and multivariable linear regression analysis for the severity of pancreatitis
| sTIM-3 | IL-10 | IL-6 | BISAP | APACHE-II | MCTSI | |
|---|---|---|---|---|---|---|
| B (95%CI) P-value | B (95%CI) P-value | B (95%CI) P-value | B (95%CI) P-value | B (95%CI) P-value | B (95%CI) P-value | |
| Model 1 (unadjusted) | ||||||
| MAP | Reference | Reference | Reference | Reference | Reference | Reference |
| MSAP |
551.186 (270.440,831.932) 0.001 |
−241.637(− 482.203, − 1.070) 0.052 |
76.599 (51.408,101.790) < 0.001 |
1.186 (0.861,1.511) < 0.001 |
2.124 (0.240,4.007) 0.030 |
2.867 (2.296, 3.438) < 0.001 |
| SAP |
1241.082 (888.465,1593.700) < 0.001 |
− 445.827 (− 747.979, -143.675) 0.005 |
280.692 (249.052, 312.332) < 0.001 |
2.315 (1.907, 2.723) < 0.001 |
9.028 (6.662, 11.394) < 0.001 |
3.045 (2.328, 3.762) < 0.001 |
| P trend | < 0.001 | 0.012 | < 0.001 | < 0.001 | < 0.001 | < 0.001 |
| Model 2 (adjusted for temperature, pulse oxygen saturation, white blood cell count, CRP, procalcitonin and length of hospital stay) | ||||||
| MAP | Reference | Reference | Reference | Reference | Reference | Reference |
| MSAP |
477.680 (188.955, 766.405) 0.002 |
− 281.815(− 537.846, − 25.783) 0.034 |
70.432 (43.864,97.000) < 0.001 |
1.024 (0.758, 1.290) < 0.001 |
1.645(− 0.138, 3.428) 0.074 |
2.870 (2.271, 3.468) < 0.001 |
| SAP |
1188.910 (821.672, 1556.148) < 0.001 |
−429.235(− 754.890, − 103.581) 0.012 |
282.954 (249.162, 316.747) < 0.001 |
2.263 (1.925, 2.601) < 0.001 |
8.470 (6.202, 10.738) < 0.001 |
3.049 (2.287, 3.810) < 0.001 |
| P trend | < 0.001 | 0.003 | < 0.001 | < 0.001 | 0.003 | < 0.001 |
| Model 3 (adjusted for sTIM-3, IL-6, IL-10 on the basis of adjusted Model 2) | ||||||
| MAP | Reference | Reference | Reference | Reference | Reference | Reference |
| MSAP |
476.109 (181.573, 770.644) 0.002 |
− 360.238(− 798.644, 78.169) 0.114 |
84.528 (53.834,115.222) < 0.001 |
1.051 (0.779, 1.323) < 0.001 |
1.123(− 0.171, 2.418) 0.093 |
2.893 (2.277, 3.510) < 0.001 |
| SAP |
819.978 (275.672, 1364.284) 0.004 |
− 776.503(− 2139.439,586.434) 0.270 |
297.153 (212.197, 382.110) < 0.001 |
2.134 (1.631, 2.637) < 0.001 |
3.715 (1.323, 6.107) 0.003 |
2.524 (1.384, 3.663) 0.001 |
| P trend | < 0.001 | 0.007 | < 0.001 | < 0.001 | 0.003 | < 0.001 |
Abbreviations: MAP Mild acute pancreatitis, MSAP Moderately severe acute pancreatitis, SAP Severe acute pancreatitis, sTIM-3 Soluble T cell immunoglobulin and mucin domain-3, APACHE II Acute physiology and chronic health evaluation II, BISAP Bedside index for severity in acute pancreatitis, MCTSI Modified computed tomography severity index
P < 0.05 was considered statistically significant