Table 3.

Risk factors of poor outcome (moderate/severe/profound developmental delay) compared to a good outcome (borderline/mild developmental delay and normal development) using univariate and multivariable logistic regression models (n = 326)

	Univariate logistic regression		Multivariate logistic regression
	OR (95% CI)	P-value	aOR (95% CI)	p-value
Age < 4 years	4.18 (1.73–10.08)	< 0.001	2.12 (0.80–5.62)	0.130
Fever	1.15 (0.63–1.68)	0.764
Convulsions	1.93 (1.11–1.87)	0.025	1.39 (0.73–2.63)	0.317
HIV infected	1.08 (0.20–5.75)	1.000
Household TB contact	0.85 (0.50–1.43)	0.590
BCG scar or documentation	1.22 (0.69–2.13)	0.575
Weight faltering/loss	1.01 (0.45–2.29)	1.000
Decreased LOC	5.28 (1.85–15.13)	< 0.001	4.68 (1.58–13.88)	0.005
Brainstem dysfunction	4.13 (2.38–7.15)	< 0.001	3.20 (1.70–6.00)	< 0.001
Motor function impaired	4.52 (2.27–9.00)	< 0.001	1.72 (0.78–3.79)	0.177
Advanced TBM stage (2b and 3)	12.20 (1.65–90.50)	0.001	1.99 (0.23–17.05)	0.530
CSF leucocytes 10–500 cells/L	0.75 (0.43–1.32)	0.379
CSF lymphocytes > 50%	1.95 (0.79–4.82)	0.173
CSF protein > 1 g/L	0.80 (0.443–1.48)	0.515
CSF glucose < 2.2 mmol/L	1.46 (0.75–2.83)	0.337
CSF- Mtb Culture positive	0.37 (0.14–0.96)	0.038	0.37 (0.13–1.06)	0.065
Radiological infarction	4.02 (2.43–6.64)	< 0.001	3.47 (1.87–6.45)	< 0.001
Basal enhancement	1.12 (0.53–2.36)	0.853
Hydrocephalus	2.36 (0.69–7.18)	0.224
Tuberculoma(s)	0.79 (0.35–1.79)	0.694

OR odds ratio, CI confidence interval, aOR adjusted odds ratio, HIV human immunodeficiency virus, TB tuberculosis, BCG Bacille Calmette-Guerin, LOC level of consciousness, TBM tuberculous meningitis, CSF cerebrospinal fluid, Mtb Mycobacterium tuberculosis