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. 2022 Dec 1;50(21):12543–12557. doi: 10.1093/nar/gkac1102

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© The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Recognition mechanisms of the bases outside the core TRE element. (A) Water-mediated recognition of dA4 by Asn507 of Nrf2. (B) Recognition of dC12* by Asn61 and Tyr64 of MafG. (C) Recognition of the 5-methy group of dT14* by Arg57 of MafG. The 5-methyl carbon of dT14* and the guanidium nitrogen of Arg57 of MafG are connected with a gray dashed line. (D) IFIE analysis. The residues near Arg57 are colored according to their interaction energy with Arg57 (red: favorable, white: neutral, and blue: unfavorable). Arg57 is colored yellow.