TABLE 1.

Characteristics of cKP and HvKP

Parameters	cKP	HvKP	Hv‐CRKP or CR‐HvKP	References
Typical infections	Pneumonia, UTI, bacteremia	PLA; lung, neck and kidney abscesses; endophthalmitis; necrotizing fasciitis; meningitis; pneumonia; cellulitis; myositis; septic arthritis; osteomyelitis	Combined infections by cKP and HvKP	19, 26, 27, 28, 29, 30, 31, 32, 33
Susceptible populations	Immunocompromised (diabetics, patients with malignancies or transplant, bedridden individuals)	Diabetics, otherwise healthy individuals	Combined populations	19, 20, 28, 29, 34, 35, 36, 37
Serotypes	K1‐K79	Mostly K1 and K2, seldom K5 and K57	K64, K47, K20, K2 and K20	1, 28, 29, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50
Siderophores (positive rates, %)	Enterobactin (100), yersiniabactin (17–46), salmochelin (2–4), aerobactin (6)	Enterobactin (100), yersiniabactin (90), salmochelin (>90), aerobactin (>93)	Enterobactin (100), yersiniabactin (90), salmochelin (40), aerobactin (>93)	40, 51, 52, 53, 54, 55, 56
Geographical prevalence	Worldwide	Mostly the Asian Pacific Rim, the trend to the world	Mainly Asia, the trend to the world	29, 30, 32, 38, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76
Commonly acquired infection type	Primarily nosocomial	Community acquired	Often nosocomial and seldom community‐acquired	29, 59, 77, 78, 79, 80
Drug‐resistance	Frequent (for example ESBLs and carbapenemase‐producing)	Rare except penicillin‐resistance	Carbapenemase‐producing	9, 19, 28, 29, 81, 82

Abbreviations: cKP, classical Klebsiella pneumoniae; CR‐HvKP, carbapenem‐resistant hypervirulent Klebsiella pneumoniae; ESBLs, extended‐spectrum β‐lactamases; HvKP, hypervirulent Klebsiella pneumoniae; Hv‐CRKP, hypervirulent carbapenem‐resistant Klebsiella pneumoniae; PLA, pyogenic liver abscess; UTI, urinary tract infection ; PLA, pyogenic liver abscess.