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A three-dimensional principal component analysis (PCA) plot (top 3 principal components) reveals a robust metabolic response at low doses of 16O radiation at day 10 (panel A) and day 30 (panel B). The 0.1 Gy dose resulted in the most significant disruptions in the metabolic profiles compared to the other doses at day 10. At day 30, on the other hand, there was a significant difference in metabolomic profiles between all tested doses and the sham group.
