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. 2022 Nov 29;50(21):12039–12057. doi: 10.1093/nar/gkac1121

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© The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 6. — Spectrum of APOBEC induced mutagenesis. The effects of APOBEC induced mutagenesis is dependent on the cellular state and can be either neutral, beneficial or detrimental to the host. APOBEC-induced DNA damage strongly correlates with their ability to displace RPA and the amount of RPA available to protect ssDNA. Low levels of APOBEC-induced mutagenesis may not have an effect in the development of drug resistance in cancer cells and as a result, cancer cells are susceptible to therapies. An optimal amount of APOBEC-induced mutagenesis may provide genomic diversity to cancer cells that can enhance tumor evolution and growth. High levels of APOBEC-induced mutagenesis can lead to cell death as a result of synthetic lethality and replication catastrophe due to RPA exhaustion.