Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Dec 2;13:1080055. doi: 10.3389/fphar.2022.1080055

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Huang, Liu, Song, Li, Gan, Shen, Holzbeierlein and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

HAMP upregulation is correlated with HAMP gene hypomethylation in ccRCC tissues. (A,B) Spearman correlation coefficient was analyzed between HAMP gene promoter methylation and HAMP expression [RNA-seq V2 RSEM, log₂ (value +1)] using the TCGA PanCancer RNA-seq dataset derived from Illumina Infinium Human Methylation BeadChips HM27 (217 ccRCC cases) and HM450 (319 ccRCC cases) platforms. (C) Spearman correlation coefficient was analyzed between HAMP gene methylation and HAMP expression. The probe cg02131995 covers the region of TSS+1297. TSS, transcription start site. (D,E) HAMP promoter methylation levels were compared quantitatively between normal kidney and ccRCC tumor tissues (D) and lymph node invasion status (E). The asterisks indicate a statistical significance (Student t-test, * p < 0.05, ** p < 0.01).