Figure 1.

Senescent cancer cells promote superior TIL activation. Anti-cancer immunosurveillance relies upon the efficient activation of the cancer-immunity cycle. Senescent cancer cells boost the ignition of this process via different modalities that include (i) the enhanced expression of MHC-I and MHC-I associated antigens; (ii) the secretion of immunostimulatory alarmins and (iii) the efficient transfer of antigens to Dendritic Cells (DCs), which in turn prime and unleash the cytotoxic action of TILs against tumor cells.