Latent Profiles capturing the spectrum of alcohol use behavior and dose‐response associations with QoL domains. Four latent Profiles were identified (Panel A) that were differentiated in terms of AUDIT total score and AUD‐treatment status (Panels B and C). In Panel B, the horizontal lines represent the WHO recommended clinical cutoffs for the AUDIT and the resulting proportions of each risk level groups were listed on the right (49.1% scored between 0 and 7; 10.9% scored between 8 and 15; 6.2% scored between 16 and 19; and 33.8% scored between 20 and 40) (32). Latent Profiles with more severe clinical characteristics had lower scores on all four domains of QoL (Panels D to G). Compared with latent Profile 1, the Cohen's d effect sizes for latent Profile 2 on QoL were 0.68 for physical domain, 0.66 for psychological domain, 0.46 for social domain, and 0.73 for environment domain. The Cohen's d effect sizes for latent Profile 3 relative to latent Profile 1 on QoL were 1.41 for physical domain, 1.41 for psychological domain, 0.84 for social domain, and 1.12 for environment domain. The Cohen's d effect sizes for latent Profile 4 relative to latent Profile 1 on QoL were 2.23 for physical domain, 2.36 for psychological domain, 1.30 for social domain, and 1.49 for environment domain.