Table 2.
Blood pressure variability measures within the first 24 h after intensive care unit admission
| BPV measure, mm Hg | Total (N = 66,549) | Cognitive outcome group, median (IQR) | |||
|---|---|---|---|---|---|
| Median (IQR) | 2.5th, 97.5th percentilea | Deliriumb (n = 13,427) | Depressed alertnessb (n = 16,250) | Preserved cognition (n = 36,872) | |
| Systolic | |||||
| Range | 65 (50–84) | 29, 140 | 73 (57–93) | 69 (53–88) | 61 (47–78) |
| SD | 13.6 (10.7–17.3) | 6.7, 27.3 | 14.9 (11.7–18.9) | 14.0 (11.1–17.8) | 13.0 (10.2–16.4) |
| ARV | 8.5 (6.7–10.7) | 4.2, 16.7 | 9.1 (7.1–11.4) | 8.4 (6.6–10.7) | 8.3 (6.6–10.4) |
| Maximum Δ | 38 (28–52) | 16, 102 | 44 (32–59) | 40 (30–55) | 36 (27–48) |
| Mean | 115 (106–127) | 90, 156 | 115 (106–128) | 114 (106–126) | 116 (106–127) |
| Diastolic | |||||
| Range | 43 (32–60) | 19, 112 | 48 (35–65) | 43 (31–59) | 42 (31–58) |
| SD | 8.5 (6.4–11.2) | 4.0, 19.5 | 9.0 (6.7–11.9) | 8.2 (6.2–10.9) | 8.4 (6.4–11.1) |
| ARV | 5.4 (3.8–7.7) | 2.2, 14.6 | 5.4 (3.9–7.9) | 4.9 (3.5–7.0) | 5.6 (3.9–7.9) |
| Maximum Δ | 28 (19–42) | 10, 92 | 31 (21–47) | 27 (18–42) | 28 (19–41) |
| Mean | 59 (53–67) | 42, 84 | 58 (52–65) | 58 (52–65) | 60 (54–68) |
ARV, average real variability; BPV, blood pressure variability, CAM-ICU, Confusion Assessment Method of the Intensive Care Unit, ICU, intensive care unit, IQR, interquartile range, SD, standard deviation
aPercentiles were used to winsorize variables for modeling purposes
bICU admissions of patients with any positive CAM-ICU scores were included in the delirium group. ICU admissions of patients who did not have a positive CAM-ICU score but who had a Glasgow Coma Scale score < 15 and/or Full Outline of UnResponsiveness score < 16 were included in the depressed alertness group