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. 2022 Dec 16;8(50):eabq6720. doi: 10.1126/sciadv.abq6720

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Fig. 4. — (A) Average whole-cell I_Kr current traces for WT (left) and edited (right) hiPSC-CMs show diminished I_Kr in edited cells. I_Kr is calculated as the subtraction of I_K current by I_K + E-4031 current. The voltage protocol is inset. (B) I_Kr current density measured at steady-state time points at 40 and −50 mV (as marked by red arrowheads in voltage inset). *P < 0.05; specifically at 40 mV, P = 0.017 and −50 mV, P = 0.036.