Table 3.
Linear regression results for regional 31P measurements with whole brain FDG SUV in the AD high-risk cohort (N = 20). Significant correlations (P < 0.01) are shown in bold. Trends (0.01 ≤ P < 0.05) are italicized.
| Regression variables | 31P-MRS Region | α | β | R2 | P |
|---|---|---|---|---|---|
| PCr/ATP vs. FDG | AD meta region | −1.84 | 3.22 | 0.361 | 0.0050 |
| PCr/ATP vs. FDG | Inferior parietal lobe | −1.49 | 2.73 | 0.329 | 0.0082 |
| PCr/ATP vs. FDG | Inferior temporal cortex | −3.04 | 4.69 | 0.344 | 0.0066 |
| PCr/ATP vs. FDG | Middle frontal gyrus | −0.66 | 1.81 | 0.070 | 0.2599 |
| PCr/ATP vs. FDG | Posterior cingulate cortex | −0.56 | 1.66 | 0.078 | 0.2328 |
| PCr/ATP vs. FDG | Precuneus | −1.03 | 2.21 | 0.219 | 0.0375 |
| PCr/ATP vs. FDG | Prefrontal cortex | −0.90 | 2.07 | 0.065 | 0.2774 |
| PCr/ATP vs. FDG | Superior temporal cortex | −2.26 | 3.77 | 0.307 | 0.0113 |
| PCr/ATP vs. FDG | Thalamus | −1.76 | 3.02 | 0.383 | 0.0036 |
| Pi/ATP vs. FDG | AD meta region | −0.98 | 1.40 | 0.409 | 0.0024 |
| Pi/ATP vs. FDG | Inferior parietal lobe | −0.93 | 1.38 | 0.325 | 0.0087 |
| Pi/ATP vs. FDG | Inferior temporal cortex | −1.44 | 1.86 | 0.580 | 0.0001 |
| Pi/ATP vs. FDG | Middle frontal gyrus | −0.46 | 0.82 | 0.171 | 0.0698 |
| Pi/ATP vs. FDG | Posterior cingulate cortex | −0.32 | 0.70 | 0.055 | 0.3175 |
| Pi/ATP vs. FDG | Precuneus | −0.60 | 1.04 | 0.113 | 0.1473 |
| Pi/ATP vs. FDG | Prefrontal cortex | −0.49 | 0.86 | 0.168 | 0.0725 |
| Pi/ATP vs. FDG | Superior temporal cortex | −1.09 | 1.50 | 0.479 | 0.0007 |
| Pi/ATP vs. FDG | Thalamus | −0.75 | 1.16 | 0.229 | 0.0328 |
| PME/PDE vs. FDG | AD meta region | −1.49 | 2.89 | 0.273 | 0.0182 |
| PME/PDE vs. FDG | Inferior parietal lobe | −1.05 | 2.56 | 0.121 | 0.1335 |
| PME/PDE vs. FDG | Inferior temporal cortex | −2.23 | 3.35 | 0.260 | 0.0217 |
| PME/PDE vs. FDG | Middle frontal gyrus | −0.36 | 1.84 | 0.012 | 0.6456 |
| PME/PDE vs. FDG | Posterior cingulate cortex | −0.31 | 1.96 | 0.015 | 0.6037 |
| PME/PDE vs. FDG | Precuneus | −1.04 | 2.63 | 0.146 | 0.0961 |
| PME/PDE vs. FDG | Prefrontal cortex | −0.43 | 1.86 | 0.028 | 0.4769 |
| PME/PDE vs. FDG | Superior temporal cortex | −1.82 | 3.13 | 0.272 | 0.0185 |
| PME/PDE vs. FDG | Thalamus | −1.30 | 2.79 | 0.195 | 0.0511 |
| pH vs. FDG | AD meta region | −0.08 | 7.09 | 0.127 | 0.1238 |
| pH vs. FDG | Inferior parietal lobe | −0.05 | 7.05 | 0.021 | 0.5412 |
| pH vs. FDG | Inferior temporal cortex | −0.14 | 7.18 | 0.128 | 0.1210 |
| pH vs. FDG | Middle frontal gyrus | −0.09 | 7.09 | 0.121 | 0.1326 |
| pH vs. FDG | Posterior cingulate cortex | −0.11 | 7.10 | 0.137 | 0.1085 |
| pH vs. FDG | Precuneus | −0.04 | 7.03 | 0.008 | 0.7066 |
| pH vs. FDG | Prefrontal cortex | −0.10 | 7.11 | 0.091 | 0.1961 |
| pH vs. FDG | Superior temporal cortex | −0.09 | 7.11 | 0.091 | 0.1965 |
| pH vs. FDG | Thalamus | −0.11 | 7.10 | 0.118 | 0.1376 |
α: linear regression slope. β: linear regression intercept. R2: linear regression coefficient of determination.