Table 2.
Associations of lipogenesis-related species, measured using lipidomics, with body mass index and glucose concentrations at intervals post glucose load in the oral glucose tolerance test in obese pregnant women (n = 867)
| Lipid species | BMI | Glucose at 0 hours | Glucose at 1 hour | Glucose at 2 hours | Homa2-IR score |
|---|---|---|---|---|---|
| DG(32:0) | 0.01 (0.00 to 0.03) | 0.40 (0.27 to 0.52)*** | 0.11 (0.08 to 0.14)*** | 0.13 (0.08 to 0.17)*** | 0.35 (0.02 to 0.05)*** |
| DG(32:1) | 0.00 (−0.01 to 0.02) | 0.14 (0.00 to 0.27)* | 0.03 (−0.01 to 0.07) | 0.02 (−0.02 to 0.07) | 0.04 (>−0.01 to 0.03) |
| DG(34:1) | 0.01 (0.00 to 0.03) | 0.16 (0.03 to 0.29)* | 0.07 (0.04 to 0.10)*** | 0.04 (0.00 to 0.09)* | 0.02 (>−0.01 to 0.04) |
| TG(46:0) | 0.00 (−0.02 to 0.01) | 0.30 (0.17 to 0.43)*** | 0.07 (0.03 to 0.10)*** | 0.07 (0.02 to 0.11)** | 0.03 (0.01 to 0.05)** |
| TG(46:1) | −0.01 (−0.02 to 0.01) | 0.21 (0.09 to 0.34)*** | 0.05 (0.02 to 0.09)** | 0.04 (−0.01 to 0.08) | 0.03 (0.01 to 0.05)** |
| TG(48:0) | 0.01 (−0.01 to 0.02) | 0.43 (0.30 to 0.55)*** | 0.11 (0.08 to 0.15)*** | 0.12 (0.08 to 0.17)*** | 0.04 (0.02 to 0.06)*** |
| TG(48:1) | −0.01 (−0.02 to 0.01) | 0.28 (0.15 to 0.41)*** | 0.08 (0.05 to 0.12)*** | 0.07 (0.03 to 0.12)*** | 0.04 (0.02 to 0.06)*** |
| TG(50:1) | 0.02 (0.01 to 0.04)** | 0.35 (0.22 to 0.47)*** | 0.11 (0.08 to 0.14)*** | 0.12 (0.07 to 0.16)*** | 0.04 (0.02 to 0.06)*** |
| TG(50:2) | 0.01 (0.00 to 0.03)* | 0.23 (0.11 to 0.36)*** | 0.09 (0.06 to 0.13)*** | 0.10 (0.05 to 0.14)*** | 0.04 (0.02 to 0.06)*** |
| Total triglycerides | <0.01 (<0.01 to 0.01) | −0.01 (−0.07 to −0.05) | <0.01 (0.01 to 0.01) | <0.01 (<0.01 to 0.01) | −0.02 (−0.02 to −0.01)*** |
Missing data: glucose at time 1 hour (n = 40); glucose at 2 hours (n = 2), and HOMA2b/HOMA2ir (n = 19).