Table 1.

Patient data.

	Group-1			Group-2
Clinical data
	P25	Median	P75	P25	Median	P75
Age	36	49	69	41.5	46	57.5
KPI	50	70	95	70	90	100
	R0a	R1b	NDc	R0	R1	ND
Surgery	1	4	2	10	8	7
Laboratory data
	Ld	Ne	Hf	L	N	H
Hemoglobin		7		3	21	1
White Blood cells	1	5	1	2	19	4
Platelets	4	3		5	20
T cells	2	4		13	12
B cells	6			22	2	1
NK cells	3	3		15	10
NK cell function	5		1	13	8	2
CD4 IFNg	1	4		1	19	2
CD4 IL4	1	5		2	13	8
	CCC−g	CCC + PDL1−h	CCC + PDL1+i	CCC−	CCC + PDL1−	CCC + PDL1+
CCC	2	2	1	9	9	5
Treatment data
ICD therapy
Total NDVj injections	6	15	24	24	42	47
Total mEHTk sessions	4	11	24	17	39	46
Active specific immunotherapy with IO-Vac®
	P25	Median	P75	P25	Median	P75
IO-Vac®	1	2	2	1	2	2
Total DCs (×106)	11.6	15.4	38.3	7.2	24	36.45
Source of tumor antigens
	mEVl	TLm	mEV + TL	mEV	TL	mEV + TL
	6	1		14	1	5

^aDocumented total resection.

^bDocumented less than total resection.

^cExtent of resection not documented.

^dL = lower than laboratory reference level.

^eN = within laboratory reference level.

^fH = above laboratory reference level.

^gCCC−: no circulating cancer cells detected in blood (www.biofocus.de).

^hCCC + PDL−: CCC detected, but mRNA expression for PDL1 below limit.

ⁱCCC + PDL1+ : CCC detected, and mRNA expression for PDL1 above limit.

^jNDV: Newcastle Disease Virus.

^kmEHT: modulated electrohyperthermia.

^lDCs loaded with ICD therapy-induced serum-derived antigenic extracellular microvesicles and apopotitic bodies.

^mDCs loaded with tumor lysate.