Table 3.

Ongoing clinical trials investigating pulpotomy in mature teeth with symptomatic irreversible pulpitis

Study design	Study title	Estimated enrolment	Estimated completion	Trial registry	Trial identifier and location
RCT	Success and quality of life following complete pulpotomy and root canal treatment in teeth with clinical signs indicative of irreversible pulpitis	100	August 2022	ClinicalTrials.gov	NCT05190406 India
Multi-centre RCT	Pulpotomy vs. root canal treatment in managing irreversible pulpitis	168	April 2023	ClinicalTrials.gov	NCT03956199 U.K
RCT	Full pulpotomy vs. partial pulpotomy in the management of teeth with clinical diagnosis of irreversible pulpits: a randomised clinical trial	200	January 2024	ClinicalTrials.gov	NCT05279820 Jordan
RCT	Quality of life, satisfaction and outcome after full pulpotomy compared to root canal therapy	60	January 2024	ClinicalTrials.gov	NCT05279781 Jordan
Multi-centre RCT	Traditional or minimally invasive endodontics for managing carious teeth with symptomatic pulpitis - a pragmatic randomised trial in general dental practice in Northern Ireland (REFORM)	164	April 2024	ISRCTN	49302282 U.K
Multi-centre non-randomised	Pulpotomy for the management of irreversible pulpitis in mature teeth - (PIP trial) feasibility study	40	June 2024	ISRCTN	17973604 U.K
RCT	Comparative effectiveness of VPT vs. RCTx in the management of irreversible pulpitis	120	March 2028	ClinicalTrials.gov	NCT04922229 U.S.A
Key: RCT = randomised controlled trial VPT = vital pulp therapy RCTx = root canal treatment ISRCTN = international standard randomised controlled trial number