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. 2022 Nov 24;29(12):1159–1169. doi: 10.1038/s41594-022-00857-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — a) Structural super-position of TBP(red) bound TATA-less U1 promoter (cyan/blue) on to TBP (grey) bound to TATA box sequence (PDB: 1YTF)(Tan et al.,²⁶). The comparison shows that TBP binds to the TATA-less sequence in a canonical fashion and bends the DNA by 90°. b-e) Cartoon representation of the individual structures of SNAPc subunits SNAPC1, 3, 4 and 5 displaying its secondary structure elements as labelled. The N and C termini of all subunits are indicated.